Phenotypes associated with this allele

• Allele Symbol: Bambi^tm1Mahu
• Allele Name: targeted mutation 1, Maria A Hurle
• Allele ID: MGI:4437820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bambi^tm1Mahu/Bambi^tm1Mahu	B6.Cg-Bambi^tm1Mahu	MGI:4437822
ht2	Bambi^tm1Mahu/Bambi^+	B6.Cg-Bambi^tm1Mahu	MGI:4437823

Genotype
MGI:4437822

hm1

• Allelic Composition: Bambi^tm1Mahu/Bambi^tm1Mahu
• Genetic Background: B6.Cg-Bambi^tm1Mahu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal pain threshold ( J:157943 )

• following sciatic nerve crush injury or spared nerve injury, mice exhibit less mechanical allodynia than similarly treated wild-type mice

• however, treatment with naloxone or naltrindole restores normal response

hyporesponsive to tactile stimuli ( J:157943 )

• mice exhibit reduced paw withdrawal upon mechanical stimulation compared with wild-type mice

• following sciatic nerve crush injury or spared nerve injury, mice exhibit less mechanical allodynia than similarly treated wild-type mice

• however, treatment with naloxone or naltrindole restores normal response

increased chemical nociceptive threshold ( J:157943 )

• during both the acute and tonic phases

increased thermal nociceptive threshold ( J:157943 )

• at 45, 47, 49, and 50 degrees Celcius, mice exhibit increased thermal nociception threshold compared with wild-type mice

• however, treatment with naloxone restores normal response

Genotype
MGI:4437823

ht2

• Allelic Composition: Bambi^tm1Mahu/Bambi⁺
• Genetic Background: B6.Cg-Bambi^tm1Mahu

behavior/neurological

hyporesponsive to tactile stimuli ( J:157943 )

• intermediate to wild-type and homozygous mice

increased thermal nociceptive threshold ( J:157943 )

• intermediate to wild-type and homozygous mice at 45, 47, 49, and 50 degrees Celcius