Phenotypes associated with this allele

• Allele Symbol: Ptprt^tm1Sata
• Allele Name: targeted mutation 1, Masanobu Satake
• Allele ID: MGI:4437410
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptprt^tm1Sata/Ptprt^tm1Sata	B6.129P2-Ptprt^tm1Sata	MGI:4437411
hm2	Ptprt^tm1Sata/Ptprt^tm1Sata	involves: 129P2/OlaHsd	MGI:6690626

Genotype
MGI:4437411

hm1

• Allelic Composition: Ptprt^tm1Sata/Ptprt^tm1Sata
• Genetic Background: B6.129P2-Ptprt^tm1Sata

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:157542 )

• 17 of the 20 homozygous mice develop visible colon tumors induced by azoxymethane, compared with none develop tumor in wild-type mice

neoplasm

increased colon adenoma incidence ( J:157542 )

• 17 of the 20 homozygous mice develop visible colon adenomas induced by azoxymethane

• average 1.5 tumors per mouse

• highly proliferative dysplastic cells as indicated by Ki-67 immunohistochemistry staining

increased incidence of tumors by chemical induction ( J:157542 )

• 17 of the 20 homozygous mice develop visible colon tumors induced by azoxymethane, compared with none develop tumor in wild-type mice

digestive/alimentary system

increased colon adenoma incidence ( J:157542 )

• 17 of the 20 homozygous mice develop visible colon adenomas induced by azoxymethane

• average 1.5 tumors per mouse

• highly proliferative dysplastic cells as indicated by Ki-67 immunohistochemistry staining

Genotype
MGI:6690626

hm2

• Allelic Composition: Ptprt^tm1Sata/Ptprt^tm1Sata
• Genetic Background: involves: 129P2/OlaHsd

nervous system

impaired neuron differentiation ( J:298303 )

• newborn granule cells exhibit delayed development and differentiation with reduced doublecortin expression and neurite length compared wild-type cells

decreased neuronal stem cell self-renewal ( J:298303 )

enhanced long-term potentiation ( J:298303 )

decreased miniature inhibitory postsynaptic current frequency ( J:298303 )

• decreased frequency in the dentate gyrus

behavior/neurological

behavior/neurological phenotype ( J:298303 )

N • mice exhibit normal motor functions, social interaction, anxiety, learning and memory

behavioral despair ( J:298303 )

• in a tail suspension test, forced swim test, and sucrose preference test

• however, treatment with imipramine or allopregnanolone reduced depression-like behaviors

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:298303 )

N • mice exhibit normal glutamate levels in the hippocampus

decreased gamma-aminobutyric acid level ( J:298303 )

• reduced GABA levels in the dentate gyrus

• however, levels in the CA3 region are normal

cellular

impaired neuron differentiation ( J:298303 )

• newborn granule cells exhibit delayed development and differentiation with reduced doublecortin expression and neurite length compared wild-type cells