Phenotypes associated with this allele

• Allele Symbol: Nr1h2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4437128
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1h2^tm1Dgen/Nr1h2^tm1Dgen	B6.129-Nr1h2^tm1Dgen	MGI:4437129

Genotype
MGI:4437129

hm1

• Allelic Composition: Nr1h2^tm1Dgen/Nr1h2^tm1Dgen
• Genetic Background: B6.129-Nr1h2^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal skeleton physiology ( J:157551 )

• increased proteoglycan degradation following IL-1beta stimulation as reflected by the total amount of aggrecan released into the culture medium compared with cartilage explants from wild-type mice

• about 5 times higher prostaglandinE2(PGE2) production by mouse hip cartilage upon IL-1beta treatment compared with cartilage explants from wild-type mice

• no gross abnormalities of joints structure at 3 weeks of age