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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pkd1tm1Gztn
targeted mutation 1, Thomas Natoli
MGI:4437121
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4819716


Genotype
MGI:4819716
cn1
Allelic
Composition
Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (3 available); any Gt(ROSA)26Sor mutation (499 available)
Pkd1tm1Gztn mutation (0 available); any Pkd1 mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• tamoxifen treated mice develop kindey cysts
• however, treatment with Genz-123346 inhibits cystogenesis
• tamoxifen-treated mice exhibit progressive renal function decline over 4 to 5 weeks
• however, treament with Genz-123346 improves kidney fucntion

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
J:162080





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory