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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pkd1tm1Gztn
targeted mutation 1, Thomas Natoli
MGI:4437121
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6 MGI:4819716


Genotype
MGI:4819716
cn1
Allelic
Composition		 Pkd1tm1Gztn/Pkd1tm1Gztn
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Pkd1tm1Gztn mutation (0 available); any Pkd1 mutation (153 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
polycystic kidney ( J:162080 )
• tamoxifen treated mice develop kindey cysts
• however, treatment with Genz-123346 inhibits cystogenesis
abnormal kidney physiology ( J:162080 )
• tamoxifen-treated mice exhibit progressive renal function decline over 4 to 5 weeks
• however, treament with Genz-123346 improves kidney fucntion

growth/size/body
polycystic kidney ( J:162080 )
• tamoxifen treated mice develop kindey cysts
• however, treatment with Genz-123346 inhibits cystogenesis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
polycystic kidney disease 1 DOID:0110858 OMIM:173900
 J:162080




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory