Phenotypes associated with this allele

• Allele Symbol: Ndfip2^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4436082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndfip2^tm1a(EUCOMM)Hmgu/Ndfip2^tm1a(EUCOMM)Hmgu	C57BL/6N-Ndfip2^tm1a(EUCOMM)Hmgu	MGI:5806244

Genotype
MGI:5806244

hm1

• Allelic Composition: Ndfip2^{tm1a(EUCOMM)Hmgu}/Ndfip2^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ndfip2^{tm1a(EUCOMM)Hmgu}
• Cell Lines: HEPD0550_6_G09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating unsaturated transferrin level ( J:235779 )

♀ • on a low iron diet, female homozygotes fail to show a significant decrease in transferrin saturation levels, unlike wild type females

abnormal iron homeostasis ( J:235779 )

♀ • female, but not male, homozygotes exhibit a significant increase in total protein levels of the divalent metal-ion transporter-1 SLC11A2 (DMT1, the primary non-heme iron importer in mammals) in the liver, with an increase in hepatic DMT1-positive puncta relative to wild-type controls

♀ • however, on a low iron diet, homozygotes of both sexes exhibit normal DMT1 protein levels in the duodenum with no differences in transport activity detected in isolated enterocytes relative to wild-type controls

abnormal circulating iron level ( J:235779 )

♀ • on a low iron diet, female homozygotes fail to show a significant decrease in serum iron levels, unlike wild type females

abnormal liver iron level ( J:235779 )

♂ • on a low iron diet, male homozygotes fail to show a significant decrease in liver iron levels, unlike wild-type males

decreased liver iron level ( J:235779 )

♀ • on a low iron diet, female homozygotes exhibit a significant decrease in liver iron content relative to wild-type females

increased liver iron level ( J:235779 )

♀ • on a normal iron diet, female homozygotes show a significant increase in liver iron levels and Perl's staining relative to wild-type females

liver/biliary system

abnormal liver iron level ( J:235779 )

♂ • on a low iron diet, male homozygotes fail to show a significant decrease in liver iron levels, unlike wild-type males

decreased liver iron level ( J:235779 )

♀ • on a low iron diet, female homozygotes exhibit a significant decrease in liver iron content relative to wild-type females

increased liver iron level ( J:235779 )

♀ • on a normal iron diet, female homozygotes show a significant increase in liver iron levels and Perl's staining relative to wild-type females

hematopoietic system

hematopoietic system phenotype ( J:235779 )

N • homozygotes show no significant differences in any of the hematological parameters measured relative to wild-type controls