Phenotypes associated with this allele

• Allele Symbol: Sparc^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432869
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sparc^tm1a(EUCOMM)Wtsi/Sparc^tm1a(EUCOMM)Wtsi	B6Dnk;B6Brd;B6N-Tyr^c-Brd Sparc^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6272826
hm2	Sparc^tm1a(EUCOMM)Wtsi/Sparc^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Sparc^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781761

Genotype
MGI:6272826

hm1

• Allelic Composition: Sparc^{tm1a(EUCOMM)Wtsi}/Sparc^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Dnk;B6Brd;B6N-Tyr^c-Brd Sparc^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0060_1_A07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/hair pigmentation ( J:232539 )

pigmentation

abnormal coat/hair pigmentation ( J:232539 )

craniofacial

abnormal incisor color ( J:232539 )

growth/size/body

abnormal incisor color ( J:232539 )

skeleton

abnormal incisor color ( J:232539 )

Genotype
MGI:5781761

hm2

• Allelic Composition: Sparc^{tm1a(EUCOMM)Wtsi}/Sparc^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Sparc^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0060_1_A07

Data Sources

IMPC Data for Sparc

craniofacial

abnormal tooth morphology ( J:175295 )

♀

IMPC - WTSI

abnormal incisor color ( J:175295 )

IMPC - WTSI

growth/size/body

abnormal tooth morphology ( J:175295 )

♀

IMPC - WTSI

abnormal incisor color ( J:175295 )

IMPC - WTSI

decreased lean body mass ( J:165965 )

IMPC - WTSI

decreased body weight ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

decreased body length ( J:165965 )

IMPC - WTSI

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:175295 )

♂

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

limbs/digits/tail

abnormal humerus morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tibia morphology ( J:175295 )

♀

IMPC - WTSI

pigmentation

abnormal coat/hair pigmentation ( J:175295 )

IMPC - WTSI

skeleton

abnormal tooth morphology ( J:175295 )

♀

IMPC - WTSI

abnormal incisor color ( J:175295 )

IMPC - WTSI

abnormal humerus morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tibia morphology ( J:175295 )

♀

IMPC - WTSI

decreased bone mineral content ( J:165965 )

IMPC - WTSI

decreased bone mineral density ( J:165965 )

IMPC - WTSI

vision/eye

abnormal eye morphology ( J:165965 , J:175295 )

IMPC - WTSI (J:175295)

IMPC - WTSI ♂ (J:165965)

abnormal lens morphology ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

cataract ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

cardiovascular system

decreased heart weight ( J:165965 )

♂

IMPC - WTSI