Phenotypes associated with this allele

• Allele Symbol: Setd5^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4432631
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setd5^tm1a(EUCOMM)Wtsi/Setd5^tm1a(EUCOMM)Wtsi	C57BL/6N-Setd5^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5631529
ht2	Setd5^tm1a(EUCOMM)Wtsi/Setd5^+	C57BL/6N-Setd5^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706088

Genotype
MGI:5631529

hm1

• Allelic Composition: Setd5^{tm1a(EUCOMM)Wtsi}/Setd5^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Setd5^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0036_3_F05

Data Sources

IMPC Data for Setd5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal visceral yolk sac morphology ( J:261316 )

• yolk sac abnormalities

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5706088

ht2

• Allelic Composition: Setd5^{tm1a(EUCOMM)Wtsi}/Setd5⁺
• Genetic Background: C57BL/6N-Setd5^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0036_3_F05

Data Sources

IMPC Data for Setd5

behavior/neurological

absent pinna reflex ( J:211773 )

♀

IMPC - WTSI

decreased grip strength ( J:211773 )

IMPC - WTSI

cardiovascular system

persistent right dorsal aorta ( J:239583 )

DMDD

right aortic arch ( J:239583 )

DMDD

absent brachiocephalic trunk ( J:239583 )

DMDD

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

symmetric azygos veins ( J:239583 )

DMDD

abnormal ductus venosus topology ( J:239583 )

DMDD

abnormal ductus venosus valve topology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

ductus venosus stenosis ( J:239583 )

DMDD

abnormal hepatic portal vein connection ( J:239583 )

DMDD

dilated hepatic portal vein ( J:239583 )

DMDD

enlarged orbital veins ( J:239583 )

DMDD

enlarged paraumbilical vein ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

abnormal superior vena cava morphology ( J:239583 )

DMDD

absent pectinate muscle ( J:239583 )

DMDD

persistent truncus arteriosus ( J:239583 )

DMDD

abnormal coronary sinus morphology ( J:239583 )

DMDD

double outlet right ventricle ( J:239583 )

DMDD

double inlet heart left ventricle ( J:239583 )

DMDD

atrial septal defect ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

abnormal aortic valve cusp morphology ( J:239583 )

DMDD

bicuspid aortic valve ( J:239583 )

DMDD

craniofacial

abnormal cranium morphology ( J:211773 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:211773 )

♂

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

IMPC - WTSI

abnormal maxilla morphology ( J:211773 )

♂

IMPC - WTSI

abnormal snout morphology ( J:211773 )

♂

IMPC - WTSI

digestive/alimentary system

intraembryonal intestine elongation ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal vitelline vein topology ( J:239583 )

DMDD

endocrine/exocrine glands

abnormal pineal gland morphology ( J:239583 )

DMDD

abnormal thymus morphology ( J:239583 )

DMDD

small thymus ( J:239583 )

DMDD

small thyroid gland ( J:239583 )

DMDD

growth/size/body

abnormal tooth morphology ( J:211773 )

♂

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

IMPC - WTSI

abnormal snout morphology ( J:211773 )

♂

IMPC - WTSI

fetal growth retardation ( J:239583 )

DMDD

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

hematopoietic system

abnormal thymus morphology ( J:239583 )

DMDD

small thymus ( J:239583 )

DMDD

increased regulatory T cell number ( J:211773 )

♀

IMPC - WTSI

increased monocyte cell number ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - WTSI

subcutaneous edema ( J:239583 )

DMDD

immune system

abnormal thymus morphology ( J:239583 )

DMDD

small thymus ( J:239583 )

DMDD

increased regulatory T cell number ( J:211773 )

♀

IMPC - WTSI

increased monocyte cell number ( J:211773 )

♀

IMPC - WTSI

enlarged lymphatic vessel ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

muscle

absent pectinate muscle ( J:239583 )

DMDD

abnormal eye muscle morphology ( J:239583 )

DMDD

nervous system

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

reduced sympathetic cervical ganglion size ( J:239583 )

DMDD

abnormal forebrain morphology ( J:239583 )

DMDD

abnormal pineal gland morphology ( J:239583 )

DMDD

abnormal olfactory bulb morphology ( J:239583 )

DMDD

abnormal hindbrain morphology ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

renal/urinary system

small kidney ( J:239583 )

DMDD

skeleton

abnormal cranium morphology ( J:211773 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:211773 )

♂

IMPC - WTSI

abnormal incisor morphology ( J:211773 )

IMPC - WTSI

abnormal maxilla morphology ( J:211773 )

♂

IMPC - WTSI

abnormal cervical rib ( J:239583 )

DMDD

vertebral fusion ( J:211773 )

♂

IMPC - WTSI

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD

abnormal optic stalk morphology ( J:239583 )

DMDD