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Allele Symbol Allele Name Allele ID |
Agpat3tm1a(EUCOMM)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4432492 |
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| Summary |
4 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• oxidized phosphatidylcholine (PC) generated from docosahexaenoic acid-containing phosphatidylcholine (PC-DHA) is decreased in retinas
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• structure of the inner segment is disorganized
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• docosahexaenoic acid-containing phospholipids (PL-DHA) are almost absent while phospholipid-containing arachidonic acid (PL-AA) levels are increased in the outer segment of the retina
• incomplete elenogation of the outer segement is seen in 3-8 week old mice
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• retinas show disruption of the disc structure in 3 week old mice, showing highly disorganized but membranous disc-like structures at the basal side of the outer segment
• abnormal discs are parallel rather than perpendicular to the axoneme
• however, no changes in the inner segment and the connection cilium as the inner segment-outer segment junction are seen
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• the outer segment length is shorted in 3 week old mice
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• structure of the outer segment is disorganized
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• outer nuclear layer is thinner in 6- and 8-week old mice
• however, the inner nuclear layer thickness is similar to wild-type mice
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• retinal degeneration is not caused by phototoxicity as indicated by decreased outer segment/inner segment and outer nuclear layers in both mice housed under dark conditions for 2 weeks and under normal light/dark cycle conditions
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• dark-adapted ERG shows 80% decrease in a-wave amplitude and light-adapted ERG shows 80% decrease in a-wave amplitude in 8 week old mice
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• dark-adapted ERG shows 50% decrease in b-wave amplitude and light-adapted ERG shows 70% decrease in b-wave amplitude in 8 week old mice
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• mice exhibit loss of visual function
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• structure of the inner segment is disorganized
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• docosahexaenoic acid-containing phospholipids (PL-DHA) are almost absent while phospholipid-containing arachidonic acid (PL-AA) levels are increased in the outer segment of the retina
• incomplete elenogation of the outer segement is seen in 3-8 week old mice
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• retinas show disruption of the disc structure in 3 week old mice, showing highly disorganized but membranous disc-like structures at the basal side of the outer segment
• abnormal discs are parallel rather than perpendicular to the axoneme
• however, no changes in the inner segment and the connection cilium as the inner segment-outer segment junction are seen
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• the outer segment length is shorted in 3 week old mice
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• structure of the outer segment is disorganized
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• docosahexaenoic acid-containing phospholipids (PL-DHA) are almost absent in the outer segment of the retina
• phospholipid-containing arachidonic acid (PL-AA) levels are increased in the outer segment of the retina
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• without an increase in male germ cell apoptosis
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• bent backward wrapped in membranous structures from the Sertoli cells
• excessive cytoplasm around the head
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• membranous structures from the Sertoli cells wraps around the sperm head
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• using male sperm and wild-type eggs with or without zona pellucida
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• reduced DHA-containing phospholipids in the testes
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• without an increase in male germ cell apoptosis
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• bent backward wrapped in membranous structures from the Sertoli cells
• excessive cytoplasm around the head
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• membranous structures from the Sertoli cells wraps around the sperm head
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - WTSI
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IMPC - WTSI
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IMPC - WTSI
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IMPC - WTSI
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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