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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bmftm1Rjd
targeted mutation 1, Roger J Davis
MGI:4421178
Summary 3 genotypes


Genotype
MGI:4421198
hm1
Allelic
Composition		 Bmftm1Rjd/Bmftm1Rjd
Genetic
Background		 B6.129S6-Bmftm1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmftm1Rjd mutation (1 available); any Bmf mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell apoptosis ( J:153652 )
• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes
enlarged spleen ( J:153652 )
• moderately enlarged spleen
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased splenocytes number (about 1.5 fold)

reproductive system
vagina atresia ( J:153652 )
• imperforate vagina in 22% of female mice
hydrometrocolpos ( J:153652 )
• hydrometrocolpos in 22% of female mice

immune system
decreased T cell apoptosis ( J:153652 )
• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes
enlarged spleen ( J:153652 )
• moderately enlarged spleen
increased B cell number ( J:153652 )
• a moderate increase in the number of B cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a moderate increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• increased splenocytes number (about 1.5 fold)

cellular
decreased T cell apoptosis ( J:153652 )
• increased viability of CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

growth/size/body
enlarged spleen ( J:153652 )
• moderately enlarged spleen




Genotype
MGI:4421201
cx2
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
Bmftm1Rjd/Bmftm1Rjd
Genetic
Background		 B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (32 available)
Bmftm1Rjd mutation (1 available); any Bmf mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:153652 )
• reduced number of homozygous mice generated from intercross of the double heterozygous compared with the expected Mendelian inheritance

growth/size/body
decreased body weight ( J:153652 )
• decreased body weight at 6 weeks old

limbs/digits/tail
interdigital webbing ( J:153652 )
• persistence of interdigital tissue on both the front and rear paws

reproductive system
vagina atresia ( J:153652 )
• imperforate vagina in female mice
hydrometrocolpos ( J:153652 )
• hydrometrocolpos in female mice

immune system
decreased T cell apoptosis ( J:153652 )
• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes
increased thymocyte number ( J:153652 )
• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes
increased B cell number ( J:153652 )
• a large increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a large increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a large increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• a larger increased number of splenocytes (>5 fold)

hematopoietic system
decreased T cell apoptosis ( J:153652 )
• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes
increased thymocyte number ( J:153652 )
• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes
increased B cell number ( J:153652 )
• a large increase in the number of B cells in the spleen
increased CD4-positive, alpha-beta T cell number ( J:153652 )
• a large increase in the number of CD4-positive T cells in the spleen
increased CD8-positive, alpha-beta T cell number ( J:153652 )
• a large increase in the number of CD8-positive T cells in the spleen
increased splenocyte number ( J:153652 )
• a larger increased number of splenocytes (>5 fold)

cellular
decreased T cell apoptosis ( J:153652 )
• increased viability of CD4-positive and CD8-positive T cells during in vitro culture of T cells purified from spleen and lymph nodes

endocrine/exocrine glands
increased thymocyte number ( J:153652 )
• increased numbers of CD4-positive, CD8-positive, and CD4/CD8 double-positive thymocytes




Genotype
MGI:4421202
cx3
Allelic
Composition		 Bcl2l11tm1.1Ast/Bcl2l11+
Bmftm1Rjd/Bmf+
Genetic
Background		 B6.129S-Bcl2l11tm1.1Ast Bmftm1Rjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Ast mutation (4 available); any Bcl2l11 mutation (32 available)
Bmftm1Rjd mutation (1 available); any Bmf mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:153652 )
• decreased body weight at 6 weeks old




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory