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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-SNCA)1Cai
transgene insertion 1, Huaibin Cai
MGI:4420977
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*G2019S)E3Cai/0
Tg(tetO-SNCA)1Cai/0 		involves: C57BL/6 MGI:4421005
cx2
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA)1Cai/0 		involves: C57BL/6 MGI:4421057


Genotype
MGI:4421005
cx1
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-LRRK2*G2019S)E3Cai/0
Tg(tetO-SNCA)1Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-LRRK2*G2019S)E3Cai mutation (1 available)
Tg(tetO-SNCA)1Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:156512 )
• somatic alpha synuclein in neurons is apparent at 1 month




Genotype
MGI:4421057
cx2
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-SNCA)1Cai/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-SNCA)1Cai mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:156512 )
N
• no alpha-synuclein accumulation is observed in neurons at 1 month




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory