About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-APBA2,-lacZ)1Ito
transgene insertion 1, Shigeyoshi Itohara
MGI:4418486
Summary 1 genotype


Genotype
MGI:4418496
cx1
Allelic
Composition
Apba2tm1Tsuz/Apba2tm1Tsuz
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APBA2,-lacZ)1Ito/0
Genetic
Background
B6.Cg-Apba2tm1Tsuz Tg(Camk2a-tTA)1Mmay Tg(tetO-APBA2,-lacZ)1Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apba2tm1Tsuz mutation (1 available); any Apba2 mutation (45 available)
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-APBA2,-lacZ)1Ito mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• with or without DOX administration, adult mice bury significantly more marbles than null mice in the marble burying test
• DOX administration to parental mice results in progeny which bury significantly fewer marbles than wild-type mice in the marble burying test
• without DOX administration mice displace significantly more food pellets from a tube than null mice in a burrowing test
• with or without DOX administration mice have decreased locomotor activity
• without DOX administration total number of resident social interactions with intruder mice are significantly increased compared to null mice in a resident-intruder test





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory