Mouse Genome Informatics
hm1
     Itm2btm2.1Ldad/Itm2btm2.1Ldad
B6.129-Itm2btm2.1Ldad
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
nervous system
nervous system phenotype ( J:155411 )
N
• absence of expected amyloid lesion (J:155411)

Mouse Models of Human Disease
 OMIM IDRef(s)
NOT Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:155411


Mouse Genome Informatics
ht2
     Itm2btm2.1Ldad/Itm2b+
B6.129-Itm2btm2.1Ldad
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:167154 )
• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice
• at 11 months, mice exhibit profound memory impairment compared with wild-type mice
abnormal spatial working memory ( J:167154 )
• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system
nervous system phenotype ( J:167154 )
N
• mice do not exhibit neuron loss or taupathy (J:167154)
reduced long term potentiation ( J:167154 )
• at 11 to 13 months

Mouse Models of Human Disease
 OMIM IDRef(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:167154


Mouse Genome Informatics
cx3
     Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0
B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:167154 )
N
• mice exhibit normal spatial working memory and novel object recognition (J:167154)