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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itm2btm2.1Ldad
targeted mutation 2.1, Luciano D'Adamio
MGI:4415610
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itm2btm2.1Ldad/Itm2btm2.1Ldad B6.129-Itm2btm2.1Ldad MGI:4415612
ht2
Itm2btm2.1Ldad/Itm2b+ B6.129-Itm2btm2.1Ldad MGI:4936849
cx3
Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0
B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad MGI:4936848


Genotype
MGI:4415612
hm1
Allelic
Composition
Itm2btm2.1Ldad/Itm2btm2.1Ldad
Genetic
Background
B6.129-Itm2btm2.1Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• absence of expected amyloid lesion (J:155411)
• absence of expected amyloid lesion (J:155411)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:155411




Genotype
MGI:4936849
ht2
Allelic
Composition
Itm2btm2.1Ldad/Itm2b+
Genetic
Background
B6.129-Itm2btm2.1Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice (J:167154)
• at 11 months, mice exhibit profound memory impairment compared with wild-type mice (J:167154)
• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice (J:167154)
• at 11 months, mice exhibit profound memory impairment compared with wild-type mice (J:167154)
• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice (J:167154)
• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice (J:167154)

nervous system
N
• mice do not exhibit neuron loss or taupathy (J:167154)
• mice do not exhibit neuron loss or taupathy (J:167154)
• at 11 to 13 months (J:167154)
• at 11 to 13 months (J:167154)

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, Itm2b-Related, 2 117300 J:167154




Genotype
MGI:4936848
cx3
Allelic
Composition
Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0
Genetic
Background
B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (3 available)
Tg(Camk2a-ITM2B)8.4Ldad mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal spatial working memory and novel object recognition (J:167154)
• mice exhibit normal spatial working memory and novel object recognition (J:167154)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory