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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itm2btm2.1Ldad
targeted mutation 2.1, Luciano D'Adamio
MGI:4415610
Summary 3 genotypes


Genotype
MGI:4415612
hm1
Allelic
Composition		 Itm2btm2.1Ldad/Itm2btm2.1Ldad
Genetic
Background		 B6.129-Itm2btm2.1Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Signs of melanosis in the meninges of the olfactory bulb and mineralization in the thalamus of Itm2btm2.1Ldad/Itm2btm2.1Ldad mice

nervous system
nervous system phenotype ( J:155411 )
N
• absence of expected amyloid lesion

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT cerebral amyloid angiopathy DOID:9246 J:155411




Genotype
MGI:4936849
ht2
Allelic
Composition		 Itm2btm2.1Ldad/Itm2b+
Genetic
Background		 B6.129-Itm2btm2.1Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:167154 )
• at 5 to 6 months and 7 to 8 months, mice spend equal time exploring novel and old objects unlike wild-type mice
• at 11 months, mice exhibit profound memory impairment compared with wild-type mice
impaired spatial working memory ( J:167154 )
• at 5 to 6 months, 7 to 8 months, and 11 months, mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice

nervous system
nervous system phenotype ( J:167154 )
N
• mice do not exhibit neuron loss or taupathy
reduced long-term potentiation ( J:167154 )
• at 11 to 13 months

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cerebral amyloid angiopathy DOID:9246 J:167154




Genotype
MGI:4936848
cx3
Allelic
Composition		 Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0
Genetic
Background		 B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (18 available)
Tg(Camk2a-ITM2B)8.4Ldad mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:167154 )
N
• mice exhibit normal spatial working memory and novel object recognition




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory