All Phenotypes Tspan12<tm1Wye> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspan12^tm1Wye/Tspan12^tm1Wye	either: B6.129S5-Tspan12^tm1Wye or FVB.129S5-Tspan12^tm1Wye	MGI:4414647
ht2	Tspan12^tm1Wye/Tspan12⁺	either: B6.129S5-Tspan12^tm1Wye or FVB.129S5-Tspan12^tm1Wye	MGI:4414652
cx3	Ndp^tm1Lex/Ndp^tm1Lex Tspan12^tm1Wye/Tspan12⁺	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)	MGI:4414650
cx4	Ndp^tm1Lex/Y Tspan12^tm1Wye/Tspan12⁺	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)	MGI:4414651
cx5	Lrp5^{Gt(OST164883)Lex}/Lrp5⁺ Tspan12^tm1Wye/Tspan12⁺	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)	MGI:4414856

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:154863 )

N	• development of the intraneural vascular plexus is normal

abnormal retina vasculature morphology ( J:154863 )

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice

• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice

• adult mice lack outer plexiform layer vasculature unlike in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

retina microaneurysm ( J:154863 )

• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice

abnormal stria vascularis vasculature morphology ( J:154863 )

• at 3 months, vessels are enlarged compared to in wild-type mice

blood vessel congestion ( J:154863 )

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

retina hemorrhage ( J:154863 )

• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice

• at P11, mice lack vertical sprouts and outer plexiform layer capillaries unlike in wild-type mice

• adult mice lack outer plexiform layer vasculature unlike in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

retina microaneurysm ( J:154863 )

• at P16, mice exhibit microaneurysms in the retina unlike in wild-type mice

retina hemorrhage ( J:154863 )

• adult mice exhibit focal hemorrhage in the retina unlike wild-type mice

persistence of hyaloid vascular system ( J:154863 )

• regression of the hyaloid vessel is delayed compared to in wild-type mice

abnormal retina nerve fiber layer morphology ( J:154863 )

• between P5 and P12, outgrowth of nerve fiber layer vasculature is moderately delayed compared to in wild-type mice

thin retina outer nuclear layer ( J:154863 )

retina gliosis ( J:154863 )

hearing/vestibular/ear

abnormal stria vascularis vasculature morphology ( J:154863 )

• at 3 months, vessels are enlarged compared to in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:158585

Allelic Composition	Tspan12^tm1Wye/Tspan12⁺
Genetic Background	either: B6.129S5-Tspan12^tm1Wye or FVB.129S5-Tspan12^tm1Wye

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tspan12^tm1Wye mutation (0 available); any Tspan12 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• at P30, retinal vertical sprouts are reduced compared to in wild-type mice

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• at P30, retinal vertical sprouts are reduced compared to in wild-type mice

Allelic Composition	Ndp^tm1Lex/Ndp^tm1Lex Tspan12^tm1Wye/Tspan12⁺
Genetic Background	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndp^tm1Lex mutation (0 available); any Ndp mutation (7 available)
Tspan12^tm1Wye mutation (0 available); any Tspan12 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

Allelic Composition	Ndp^tm1Lex/Y Tspan12^tm1Wye/Tspan12⁺
Genetic Background	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• at P15 and P30, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

Allelic Composition	Lrp5^{Gt(OST164883)Lex}/Lrp5⁺ Tspan12^tm1Wye/Tspan12⁺
Genetic Background	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^{Gt(OST164883)Lex} mutation (1 available); any Lrp5 mutation (81 available)
Tspan12^tm1Wye mutation (0 available); any Tspan12 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

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