Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5btm1Tmj mutation
(0 available);
any
Wnt5b mutation
(35 available)
|
|
|
nervous system
N |
• mice exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes
|
mortality/aging
|
• embryos die before the onset of motor neuron differentiation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4tm1Amc mutation
(2 available);
any
Wnt4 mutation
(20 available)
Wnt5btm1Tmj mutation
(0 available);
any
Wnt5b mutation
(35 available)
|
|
|
nervous system
|
• at E13.5, median motor column motor neurons at the thoracic level are decreased 58% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind-limb level, the total number of motor neurons is slightly decreased and the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice
|
|
• at the hind-limb level, the total number of motor neurons is slightly decreased compared to in wild-type mice
|
nervous system
|
• at E13.5, median motor column motor neurons at the thoracic level are decreased 59% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 62% compared to in wild-type mice
|
limbs/digits/tail
nervous system
|
• at E13.5, median motor column motor neurons at the thoracic level are decreased 63% compared to in wild-type mice
• mice exhibit a 50% reduction in median motor column motor neurons at the lumbar level compared with wild-type mice
• at the hind limb level, the total number of motor neurons is decreased 20% while the ratio of median motor column motor neurons is decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 50% compared to in wild-type mice
|
|
• at the hind limb level, the total number of motor neurons is decreased 20% compared to in wild-type mice
|
limbs/digits/tail
nervous system
|
• at E13.5, median motor column motor neurons at the thoracic level are decreased 67% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 39% compared to in wild-type mice
|
limbs/digits/tail
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt5atm1Amc mutation
(1 available);
any
Wnt5a mutation
(40 available)
Wnt5btm1Tmj mutation
(0 available);
any
Wnt5b mutation
(35 available)
|
|
|
nervous system
|
• at E13.5, median motor column motor neurons at the thoracic level are decreased 50% compared to in wild-type mice
• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased compared to in wild-type mice
|
limbs/digits/tail