Phenotypes associated with this allele

• Allele Symbol: Cd3g^tm1.1Cage
• Allele Name: targeted mutation 1.1, Carsten Geisler
• Allele ID: MGI:4398866
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd3g^tm1.1Cage/Cd3g^tm1.1Cage	B6.129P2-Cd3g^tm1.1Cage	MGI:4398876
cx2	Cd3g^tm1.1Cage/Cd3g^tm1.1Cage Tg(TcrLCMV)318Sdz/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N	MGI:4398877

Genotype
MGI:4398876

hm1

• Allelic Composition: Cd3g^tm1.1Cage/Cd3g^tm1.1Cage
• Genetic Background: B6.129P2-Cd3g^tm1.1Cage

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:153813 )

• in vesicular stomatitis virus-infected mice

decreased thymocyte number ( J:153813 )

decreased CD8-positive, alpha-beta T cell number ( J:153813 )

• the number of naive CD8+ T cells in the spleen is decreased compared to in wild-type mice

spleen hypoplasia ( J:153813 )

abnormal response to infection ( J:153813 )

• following infection with vesicular stomatitis virus or lymphocytic choriomeningitis virus, expansion of viral-specific CD8+ T cells is decreased compared to in similarly treated wild-type mice

• following infection with vesicular stomatitis virus, T cell apoptosis is increased compared to similarly infected wild-type cells

• following infection with lymphocytic choriomeningitis virus, spleen viral titers are higher than in similarly treated wild-type mice

hematopoietic system

increased T cell apoptosis ( J:153813 )

• in vesicular stomatitis virus-infected mice

decreased thymocyte number ( J:153813 )

decreased CD8-positive, alpha-beta T cell number ( J:153813 )

• the number of naive CD8+ T cells in the spleen is decreased compared to in wild-type mice

spleen hypoplasia ( J:153813 )

cellular

increased T cell apoptosis ( J:153813 )

• in vesicular stomatitis virus-infected mice

endocrine/exocrine glands

decreased thymocyte number ( J:153813 )

Genotype
MGI:4398877

cx2

• Allelic Composition: Cd3g^tm1.1Cage/Cd3g^tm1.1Cage; Tg(TcrLCMV)318Sdz/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

immune system

immune system phenotype ( J:142387 )

N

abnormal T cell physiology ( J:142387 )

abnormal response to infection ( J:142387 )

• adoptive transfer experiments demonstrate that reduced expansion of virus-specific CD8+ T cells is cell intrinsic and host independent

hematopoietic system

abnormal T cell physiology ( J:142387 )