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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-App*,-Apbb1)25Spim
transgene insertion 25, Sanjay W Pimplikar
MGI:4366527
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Camk2a-App*,-Apbb1)25Spim/0 C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim MGI:4366531


Genotype
MGI:4366531
tg1
Allelic
Composition
Tg(Camk2a-App*,-Apbb1)25Spim/0
Genetic
Background
C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
• mice exhibit age-dependent somatodendritic aggregations of phosphorylated tau protein unlike in wild-type mice
• age-dependent neuron loss is observed in mice older than 18 months in the CA3 region and to a lesser extent in the dentate gyrus unlike in wild-type mice
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

behavior/neurological
N
• mice exhibit normal excitability and exploratory behavior
• at 8 months, mice exhibit a decrease in spontaneous alteration in a Y-maze unlike wild-type mice
• however, young mice and mice treated with lithium exhibit normal working memory

homeostasis/metabolism
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

cellular
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:153738





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory