Mouse Genome Informatics
tg1
    Tg(Camk2a-App*,-Apbb1)25Spim/0
C57BL/6-Tg(Camk2a-App*,-Apbb1)25Spim
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice
• mice exhibit age-dependent somatodendritic aggregations of phosphorylated tau protein unlike in wild-type mice
• age-dependent neuron loss is observed in mice older than 18 months in the CA3 region and to a lesser extent in the dentate gyrus unlike in wild-type mice
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

behavior/neurological
N
• mice exhibit normal excitability and exploratory behavior (J:153738)
• at 8 months, mice exhibit a decrease in spontaneous alteration in a Y-maze unlike wild-type mice
• however, young mice and mice treated with lithium exhibit normal working memory

homeostasis/metabolism
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

cellular
• at 4 months, mice treated with kainic acid exhibit neuron loss similar to in aged Tg(Camk2a-App*,-Apbb1)25Spim mice but unlike similarly treated wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:153738