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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sox2tm1.1Lan
targeted mutation 1.1, Richard A Lang
MGI:4366453
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pax6tm2Pgr/Pax6tm2Pgr
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL MGI:4366457
cn2
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Scgb1a1-cre)1Kkw/0
involves: 129/Sv * C57BL/6 MGI:4430214
cn3
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
involves: C57BL/6 * FVB/N * SJL MGI:4366456


Genotype
MGI:4366457
cn1
Allelic
Composition
Pax6tm2Pgr/Pax6tm2Pgr
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (73 available)
Sox2tm1.1Lan mutation (1 available); any Sox2 mutation (47 available)
Tg(Cryaa-cre)10Mlr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lens epithelial cells accumulate posterior to the lens equator unlike in wild-type mice
• anterior lens epithelium is reduced in size compared to in wild-type mice
• lens epithelial cells fail to exhibit the cell cycle

cellular




Genotype
MGI:4430214
cn2
Allelic
Composition
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Scgb1a1-cre)1Kkw/0
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm1.1Lan mutation (1 available); any Sox2 mutation (47 available)
Tg(Scgb1a1-cre)1Kkw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Sox2tm1.1Lan/Sox2tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0 mice show cuboidal-to-squamous epithelium lacking goblet, Clara and ciliated cells in the conducting airway epithelium

respiratory system
• at 4 weeks of age, mice lack the apical cilia characteristic of ciliated cells in large bronchioles and small bronchioles
• during the first 4 weeks of life, mice show a progressive and extensive loss of normal conducting airway epithelial cells
• however, no pulmonary inflammation is observed and mice survive normally for >6 months
• at 4 weeks of age, a single layer of low cuboidal-to-squamous epithelium lacking the ''domed'' morphology characteristic of Clara cells, the apical cilia characteristic of ciliated cells, and goblet shape of mucus producing cells, is present in large bronchioles and small bronchioles
• at 4 weeks of age, the proliferation index of bronchiolar cells is reduced by 42% relative to that in wild-type lungs
• cell width increases 13%, cell height decreases 33%, and cell density decreases 12%, consistent with a shift from columnar to cuboidal-squamous morphology
• by 6 weeks of age, few ciliated cells remain in the bronchioles
• no Clara cells are identified at birth and thereafter
• loss of Clara cells occurs faster than loss of ciliated cells
• no allergen-induced goblet cell differentiation or mucus production is observed in the bronchiolar epithelium
• at 4 weeks of age, mice lack goblet cells
• goblets cells fail to form following allergen exposure

cellular
• at 4 weeks of age, mice lack the apical cilia characteristic of ciliated cells in large bronchioles and small bronchioles




Genotype
MGI:4366456
cn3
Allelic
Composition
Sox2tm1.1Lan/Sox2tm1.1Lan
Tg(Cryaa-cre)10Mlr/0
Genetic
Background
involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2tm1.1Lan mutation (1 available); any Sox2 mutation (47 available)
Tg(Cryaa-cre)10Mlr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• mice have normal eyes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory