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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Oxct1tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4364940
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Oxct1tm1a(KOMP)Wtsi/Oxct1tm1a(KOMP)Wtsi C57BL/6-Oxct1tm1a(KOMP)Wtsi MGI:4948246


Genotype
MGI:4948246
hm1
Allelic
Composition
Oxct1tm1a(KOMP)Wtsi/Oxct1tm1a(KOMP)Wtsi
Genetic
Background
C57BL/6-Oxct1tm1a(KOMP)Wtsi
Cell Lines EPD0082_1_C02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oxct1tm1a(KOMP)Wtsi mutation (1 available); any Oxct1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are alive at P2
• however, serial administration of NaHCO3 improves survival to P2-P3 and administration of glucose and NaHCO3 further improves survival

homeostasis/metabolism
• autophagy in the brain is enhanced compared to in wild-type brains
• at P0 and P1, mice exhibit progressive hyperketonemia compared with wild-type mice
• mice resuscitated with glucose exhibit refractory hyperketonemia unlike wild-type mice
• mice exhibit reduced plasma lactate concentrations compared with wild-type mice
• at P0 and P1, glucose oxidation in the brain is higher than in wild-type mice
• however, skeletal muscle glucose oxidation is normal
• ketoacidosis

nervous system
• at P0 and P1, glucose oxidation in the brain is higher than in wild-type mice
• terminal ketone body oxidation is absent in muscle and brain tissues unlike in wild-type muscle

muscle
• terminal ketone body oxidation is absent in muscle and brain tissues unlike in wild-type muscle
• at P0, skeletal muscle exhibits increased lactate oxidation compared with wild-type mice
• however, lactate oxidation is normal at P1

cellular
• autophagy in the brain is enhanced compared to in wild-type brains





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory