Phenotypes associated with this allele

• Allele Symbol: Panx1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363250
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Panx1^tm1a(KOMP)Wtsi/Panx1^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5297213
hm2	Panx1^tm1a(KOMP)Wtsi/Panx1^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5288477

Genotype
MGI:5297213

hm1

• Allelic Composition: Panx1^{tm1a(KOMP)Wtsi}/Panx1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:177671 )

• induced by kainic acid

abnormal neuron physiology ( J:177671 )

• potassium-stimulated hippocampal neurons and astrocytes do not exhibit membrane permeabilization (measured by Yo-Pro dye uptake) and exhibit attenuated ATP release compared with wild-type neurons

• in response to kainic acid, mice fail to exhibit membrane permeabilization (measured by Yo-Pro dye uptake) and exhibit decreased ATP release unlike wild-type mice

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:177671 )

• induced by kainic acid

Genotype
MGI:5288477

hm2

• Allelic Composition: Panx1^{tm1a(KOMP)Wtsi}/Panx1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

cellular

abnormal cell physiology ( J:175396 )

• mouse tracheal epithelial (MTE) cells fail to exhibit hypotonicity evoked propridium iodide unlike wild-type cells

• MTE cells exhibit slightly decreased baseline ATP and impaired hypotonicity-stimulated ATP release compared with wild-type cells

respiratory system

abnormal respiratory system physiology ( J:175396 )

• mouse tracheal epithelial (MTE) cells fail to exhibit hypotonicity evoked propridium iodide unlike wild-type cells

• MTE cells exhibit slightly decreased baseline ATP and impaired hypotonicity-stimulated ATP release compared with wild-type cells