Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hunktm1Lach mutation
(0 available);
any
Hunk mutation
(43 available)
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normal phenotype
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• viable and fertile with normal longevity, no gross morphological abnormalities and no alteration in spontaneous tumor formation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hunktm1Lach mutation
(0 available);
any
Hunk mutation
(43 available)
Tg(MMTV-Myc)#Led mutation
(0 available)
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neoplasm
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• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is about 5 fold lower compared to transgenic mice wild-type for Hunk
• a decrease in metastases is also seen when primary tumors are transplanted in nude mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hunktm1Lach mutation
(0 available);
any
Hunk mutation
(43 available)
Tg(MMTV-Myc)#Led mutation
(0 available)
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|
|
neoplasm
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• while tumor latency, multiplicity and growth rate are similar to controls, the fraction of mice with lung metastases is reduced compared to transgenic mice wild-type for Hunk but increased compared to transgenic mice that are homozygous for the mutant allele
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Analysis Tools
