Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
behavior/neurological
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• progressively lose the capability to coordinate and balance in the rotarod test and the hanging wire test
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• reduced life span
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) extends their average life span (13.7%)
• late-onset (from 12 weeks old) SB treatment extends the average life span (21.5%)
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nervous system
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• neurons in the dentate cerebellar nucleus display somal atrophy
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• extensive nuclear accumulation of Atrophin-1 and widespread nuclear inclusions in several brain regions (striatum, cortex, thalamus, red nucleus, dentate cerebellar nucleus, and Purkinje cells)
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behavior/neurological
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• progressively lose the capability to coordinate and balance in the rotarod test and the hanging wire test
• early-onset Sodium Butyrate (SB, a HDAC inhibitor) treatment (from 4 weeks old) delays the onset of motor impairments
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reproductive system