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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ttntm1Brge
targeted mutation 1, Brenda Gerull
MGI:4359790
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ttntm1Brge/Ttntm1Brge B6.Cg-Ttntm1Brge MGI:4359813
ht2
Ttntm1Brge/Ttn+ B6.Cg-Ttntm1Brge MGI:4359814


Genotype
MGI:4359813
hm1
Allelic
Composition
Ttntm1Brge/Ttntm1Brge
Genetic
Background
B6.Cg-Ttntm1Brge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttntm1Brge mutation (0 available); any Ttn mutation (538 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between E8.5 and E10.5

cardiovascular system
• at E8.5, the common ventricles are slightly enlarged with thinner ventricular walls, loosely packed endocardial cells, and pericardial edema compared to in wild-type mice
• at E9.0, the heart region appears enlarged compared to in wild-type mice
• at E9.0, the ventricles and atria are smaller than in wild-type mice without proper layer structure compared to in wild-type mice
• at E9.0, the myocardium lacks striations unlike in wild-type mice
• at E9.0
• at E8.75

embryo
• at E9.5 mice are poorly developed
• however, mice are normal at E8.5
• at E9.5 but not at E8.5

homeostasis/metabolism
• at E9.0

growth/size/body
• at E9.5 mice are poorly developed
• however, mice are normal at E8.5
• at E9.5 but not at E8.5




Genotype
MGI:4359814
ht2
Allelic
Composition
Ttntm1Brge/Ttn+
Genetic
Background
B6.Cg-Ttntm1Brge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttntm1Brge mutation (0 available); any Ttn mutation (538 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• under normal condition, mice exhibit normal cardiac function and mechanical properties
• after 2 weeks of treatment with angiotensin II, mice exhibit increased left ventricular end-diastolic diameter (LVEDD) compared with similarly treated wild-type mice
• however, a normal decrease in LVEDD a week after angiotensin II treatment is observed
• mice treated with angiotensin II or isoproterenol exhibit increased left ventricular dilation compared with similarly treated wild-type mice
• following treatment with angiotensin II or isoproterenol
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

homeostasis/metabolism
• mice treated with angiotensin II or isoproterenol exhibit left ventricular dilation, decreased fractional shortening, increased left ventricular end-diastolic diameter, and increased cardiac interstitial fibrosis compared with similarly treated wild-type mice

muscle
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Cardiomyopathy, Dilated, 1G; CMD1G 604145 J:152736





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory