Mouse Genome Informatics
hm1
    Ttntm1Brge/Ttntm1Brge
B6.Cg-Ttntm1Brge
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die between E8.5 and E10.5

cardiovascular system
• at E8.5, the common ventricles are slightly enlarged with thinner ventricular walls, loosely packed endocardial cells, and pericardial edema compared to in wild-type mice
• at E9.0, the heart region appears enlarged compared to in wild-type mice
• at E9.0, the ventricles and atria are smaller than in wild-type mice without proper layer structure compared to in wild-type mice
• at E9.0, the myocardium lacks striations unlike in wild-type mice
• at E9.0
• at E8.75

embryogenesis
• at E9.5 but not at E8.5
• at E9.5 mice are poorly developed
• however, mice are normal at E8.5

homeostasis/metabolism
• at E9.0

growth/size
• at E9.5 but not at E8.5
• at E9.5 mice are poorly developed
• however, mice are normal at E8.5


Mouse Genome Informatics
ht2
    Ttntm1Brge/Ttn+
B6.Cg-Ttntm1Brge
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
N
• under normal condition, mice exhibit normal cardiac function and mechanical properties (J:152736)
• after 2 weeks of treatment with angiotensin II, mice exhibit increased left ventricular end-diastolic diameter (LVEDD) compared with similarly treated wild-type mice
• however, a normal decrease in LVEDD a week after angiotensin II treatment is observed
• mice treated with angiotensin II or isoproterenol exhibit increased left ventricular dilation compared with similarly treated wild-type mice
• following treatment with angiotensin II or isoproterenol
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

homeostasis/metabolism
• mice treated with angiotensin II or isoproterenol exhibit left ventricular dilation, decreased fractional shortening, increased left ventricular end-diastolic diameter, and increased cardiac interstitial fibrosis compared with similarly treated wild-type mice

muscle
• following treatment with angiotensin II or isoproterenol
• after 1 and 2 weeks of treatment with angiotensin II, mice exhibit decreased fractional shortening compared with similarly treated wild-type mice
• after treatment with isoproterenol, mice exhibit reduced ejection fraction and fractional shortening compared with similarly treated wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Cardiomyopathy, Dilated, 1G; CMD1G 604145 J:152736