Phenotypes associated with this allele

• Allele Symbol: Pros1^tm1.1Ansc
• Allele Name: targeted mutation 1.1, Anne Angelillo-Scherrer
• Allele ID: MGI:4359168
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pros1^tm1.1Ansc/Pros1^tm1.1Ansc	involves: 129/Sv * C57BL/6J * FVB/N	MGI:4359174
ht2	Pros1^tm1.1Ansc/Pros1^+	involves: 129/Sv * C57BL/6J * FVB/N	MGI:4359173

Genotype
MGI:4359174

hm1

• Allelic Composition: Pros1^tm1.1Ansc/Pros1^tm1.1Ansc
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:152423 )

• although present at E17.5, no full-term mice are recovered

cardiovascular system

bruising ( J:152423 )

• at E17.5, mice exhibit bruised heads with localized signs of bleeding and or thrombosis throughout the body unlike wild-type mice

hemorrhage ( J:152423 )

• at E17.5, mice exhibit hemorrhages throughout the body including subcutaneous and intracranial unlike wild-type mice

intracranial hemorrhage ( J:152423 )

• at E17.5

hematopoietic system

increased megakaryocyte cell number ( J:152423 )

• in the liver at E17.5

thrombocytopenia ( J:152423 )

• at E17.5

liver/biliary system

hepatic necrosis ( J:152423 )

• at E17.5

decreased hepatocyte number ( J:152423 )

• at E17.5

homeostasis/metabolism

abnormal thrombosis ( J:152423 )

• at E17.5, mice exhibit thrombosis throughout the body, especially on the back, unlike wild-type mice

nervous system

intracranial hemorrhage ( J:152423 )

• at E17.5

integument

pallor ( J:152423 )

• in feet and nose at E17.5

cellular

hepatic necrosis ( J:152423 )

• at E17.5

Genotype
MGI:4359173

ht2

• Allelic Composition: Pros1^tm1.1Ansc/Pros1⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:152423 )

• mice subjected to tissue factor (TF)-induced venous thromboembolism exhibit increased mortality compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:152423 )

• mice subjected to tissue factor (TF)-induced venous thromboembolism exhibit increased number of thrombi in the lungs compared with similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:152423 )

• mice subjected to tissue factor (TF)-induced venous thromboembolism exhibit increased number of thrombi in the lungs and mortality compared with similarly treated wild-type mice