Phenotypes associated with this allele
Allelic Composition |
Npr2pwe/Npr2pwe
|
|
Genetic Background |
involves: C3H/HeJ * C57BL/6 * CAST * NAW/WI |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2pwe mutation
(1 available);
any
Npr2 mutation
(43 available)
|
|
|
mortality/aging
N |
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating matches the expected Mendelian ratio
|
Allelic Composition |
Npr2pwe/Npr2pwe
|
|
Genetic Background |
involves: C3H/HeJ * C57BL/6 * NAW/WI |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2pwe mutation
(1 available);
any
Npr2 mutation
(43 available)
|
|
|
mortality/aging
|
• Background Sensitivity: number of homozygotes produced from a heterozygote x heterozygote mating is less than the expected Mendelian ratio (12% vs. 25%)
|
growth/size/body
|
• malocculusion is frequent, but not completely penetrant
|
|
• weight is 54% of controls
|
|
• crown-rump length is 77% of controls
|
|
• dwarfism is evident by 2 weeks of age
|
limbs/digits/tail
craniofacial
|
• malocculusion is frequent, but not completely penetrant
|
reproductive system
|
• oocytes progress prematurely through meiosis
• all oocytes examined underwent premature germinal vesicle breakdown (GVBD)
• following ovulation, oocytes undergo fragmentation
|
|
• vaginal opening occurs at P33-P84
|
|
• males are sub-fertile, however, there are no obvious abnormalities in penian bone or testes histology
|
skeleton
|
• malocculusion is frequent, but not completely penetrant
|
|
• reduction in height of proliferative zone of the tibial growth plate
|
|
• reduction in height of hypertrophic zone of the tibial growth plate
|
|
• C2 vertebrae have a notch on the dorsal side
|
|
• bones formed through endochrondral ossification are reduced in length, however there is no reduction in the width of the skull, femur or ribs
|
Allelic Composition |
Npr2pwe/?
|
|
Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2pwe mutation
(1 available);
any
Npr2 mutation
(43 available)
|
|
|