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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nreptm1Wcw
targeted mutation 1, William C Wetsel
MGI:4353245
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nreptm1Wcw/Nreptm1Wcw involves: 129S1/Sv * C57BL/6NCrl MGI:4353272


Genotype
MGI:4353272
hm1
Allelic
Composition
Nreptm1Wcw/Nreptm1Wcw
Genetic
Background
involves: 129S1/Sv * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nreptm1Wcw mutation (0 available); any Nrep mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice reduce freezing in response to contextual fear conditioning with foot shock compared with similarly treated wild-type mice
• mice spend less time with male urine and more time with saline than wild-type mice
• however, mice can distinguish between male urine and saline
• at 20 minutes and 24 hours from exposure to demonstrator mouse
• in a Morris water maze, mice exhibit impaired learning the location of the hidden platform compared with wild-type mice
• fewer mice exhibit barbering compared to wild-type
• when suspended by their tails, mice spend more time immobile than wild-type mice
• latency and duration of pole-walking are increased compared to in wild-type mice
• swimming velocity in a Morris water maze is reduced during the first trial compared to in wild-type mice
• however, swimming velocity in the next three trials is normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory