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Allele Symbol Allele Name Allele ID |
GrhprGt(OST383093)Lex gene trap OST383093, Lexicon Genetics MGI:4301247 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice at 3 months of age
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• in mice at 3 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary hyperoxaluria type 2 | DOID:0111671 |
OMIM:260000 |
J:181969 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 3 months, mice exhibit increased urine glycerate compared with wild-type mice
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• in mice at 3 months of age
• in male mice fed a diet with 1% hydroxyproline
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• mice with urinary stones exhibit inflammation with mononuclear cell infiltrates in the bladder mucosa and muscle layers and epithelial erosion
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• in some mice
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• in some mice
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• 6 of 20 mice develop mild to moderate nephrocalcinosis
• male mice fed a diet with 1% hydroxyproline exhibit increased urine glycolate, oxalate excretion, renal oxalate, severe nephrocalcinosis and loss of renal function compared with wild-type mice
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• 12 of 20 mice develop urinary bladder and renal stones
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• some mice exhibit calcium oxalate monohydrate and/or calcium oxalate dehydrate stones in the kidneys and bladder
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• in male mice fed a diet with 1% hydroxyproline
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• at 3 months, mice exhibit increased plasma glycerate compared with wild-type mice
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• at 3 months, mice exhibit increased urine glycerate compared with wild-type mice
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|
• in mice at 3 months of age
• in male mice fed a diet with 1% hydroxyproline
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• male mice fed a diet with 1% hydroxyproline exhibit increased urine glycolate, oxalate excretion, renal oxalate, severe nephrocalcinosis and loss of renal function compared with wild-type mice
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• mice with urinary stones exhibit inflammation with mononuclear cell infiltrates in the bladder mucosa and muscle layers and epithelial erosion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females
• however, mice do not show changes in urinary glycolate levels
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• males fed a 1% hydroxyproline diet exhibit renal oxalosis
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• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females
• however, mice do not show changes in urinary glycolate levels
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary hyperoxaluria type 2 | DOID:0111671 |
OMIM:260000 |
J:283585 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes
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• mice fed a 1% hydroxyproline diet exhibit kidney oxalate levels approximately 1300-fold lower than in wild-type mice, indicating prevention of calcium-oxalate crystal deposition in the kidney
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• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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