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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
GrhprGt(OST383093)Lex
gene trap OST383093, Lexicon Genetics
MGI:4301247
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex B6.129S5-GrhprGt(OST383093)Lex MGI:5314653
hm2
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5315382
hm3
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:6472965
cx4
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Prodh2em1Jkni/Prodh2em1Jkni
involves: 129S5/SvEvBrd * C57BL/6J MGI:6472962


Genotype
MGI:5314653
hm1
Allelic
Composition
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Genetic
Background
B6.129S5-GrhprGt(OST383093)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GrhprGt(OST383093)Lex mutation (1 available); any Grhpr mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• in mice at 3 months of age

homeostasis/metabolism
• in mice at 3 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary hyperoxaluria type 2 DOID:0111671 OMIM:260000
J:181969




Genotype
MGI:5315382
hm2
Allelic
Composition
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GrhprGt(OST383093)Lex mutation (1 available); any Grhpr mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• at 3 months, mice exhibit increased urine glycerate compared with wild-type mice
• in mice at 3 months of age
• in male mice fed a diet with 1% hydroxyproline
• mice with urinary stones exhibit inflammation with mononuclear cell infiltrates in the bladder mucosa and muscle layers and epithelial erosion
• in some mice
• 6 of 20 mice develop mild to moderate nephrocalcinosis
• male mice fed a diet with 1% hydroxyproline exhibit increased urine glycolate, oxalate excretion, renal oxalate, severe nephrocalcinosis and loss of renal function compared with wild-type mice
• 12 of 20 mice develop urinary bladder and renal stones
• some mice exhibit calcium oxalate monohydrate and/or calcium oxalate dehydrate stones in the kidneys and bladder
• in male mice fed a diet with 1% hydroxyproline

homeostasis/metabolism
• at 3 months, mice exhibit increased plasma glycerate compared with wild-type mice
• at 3 months, mice exhibit increased urine glycerate compared with wild-type mice
• in mice at 3 months of age
• in male mice fed a diet with 1% hydroxyproline
• male mice fed a diet with 1% hydroxyproline exhibit increased urine glycolate, oxalate excretion, renal oxalate, severe nephrocalcinosis and loss of renal function compared with wild-type mice

immune system
• mice with urinary stones exhibit inflammation with mononuclear cell infiltrates in the bladder mucosa and muscle layers and epithelial erosion




Genotype
MGI:6472965
hm3
Allelic
Composition
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GrhprGt(OST383093)Lex mutation (1 available); any Grhpr mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females
• however, mice do not show changes in urinary glycolate levels
• males fed a 1% hydroxyproline diet exhibit renal oxalosis

renal/urinary system
• both males and females exhibit an increase in urinary oxalate excretion, with males excreting more urinary oxalate than females
• however, mice do not show changes in urinary glycolate levels

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
primary hyperoxaluria type 2 DOID:0111671 OMIM:260000
J:283585




Genotype
MGI:6472962
cx4
Allelic
Composition
GrhprGt(OST383093)Lex/GrhprGt(OST383093)Lex
Prodh2em1Jkni/Prodh2em1Jkni
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GrhprGt(OST383093)Lex mutation (1 available); any Grhpr mutation (13 available)
Prodh2em1Jkni mutation (0 available); any Prodh2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes
• mice fed a 1% hydroxyproline diet exhibit kidney oxalate levels approximately 1300-fold lower than in wild-type mice, indicating prevention of calcium-oxalate crystal deposition in the kidney

renal/urinary system
• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Prodh2 homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory