Phenotypes associated with this allele

• Allele Symbol: Tnrc6c^{Gt(IST11346C2)Tigm}
• Allele Name: gene trap IST11346C2, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:4001992
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnrc6c^Gt(IST11346C2)Tigm/Tnrc6c^Gt(IST11346C2)Tigm	involves: C57BL/6N	MGI:6118978

Genotype
MGI:6118978

hm1

• Allelic Composition: Tnrc6c^{Gt(IST11346C2)Tigm}/Tnrc6c^{Gt(IST11346C2)Tigm}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:248980 )

• some mice die within 6 hours after birth with cyanosis and rapid breathing

• all die within 24 hours of birth

respiratory system

abnormal lung-associated mesenchyme development ( J:248980 )

• variably thickened in small distal gas exchange sacs due to impaired thinning during sacculation and defects in microvascular maturation

• however, mice exhibit normal lung epithelial cell differentiation and cellular kinetics and composition in the distal lung

respiratory distress ( J:248980 )

• in some mice after birth

homeostasis/metabolism

cyanosis ( J:248980 )

• in some mice after birth