mortality/aging

partial lethality ( J:169236 )

• fewer than expected mice are present at P0

partial perinatal lethality ( J:169236 )

• fewer than expected mice are present at P0

skeleton

abnormal cranium morphology ( J:169236 )

• flattened in the anterior posterior axis

small cranium ( J:169236 )

• the hypertrophic chondrocyte zone is poorly organized and smaller than in wild-type mice

disorganized long bone epiphyseal plate ( J:169236 )

decreased length of long bones ( J:169236 )

• shortening is slightly more severe in distal rather than proximal limb elements

abnormal rib morphology ( J:169236 )

• ribs exhibit an irregular margin between bone and cartilage compared with wild-type mice

abnormal thoracic cage shape ( J:169236 )

• thoracic cages are constricted compared to in wild-type mice

limbs/digits/tail

preaxial polydactyly ( J:169236 )

• bilateral in hind limbs with a single extra digit longer than other digits

growth/size

growth/size phenotype ( J:169236 )

N	• mice exhibit normal sidedness, indicating normal ciliary function (J:169236)

decreased birth body size ( J:169236 )

postnatal growth retardation ( J:169236 )

renal/urinary system

renal/urinary system phenotype ( J:169236 )

N	• at P21, mice exhibit normal kidney morphology (J:169236)

vision/eye

vision/eye phenotype ( J:169236 )

N	• at P21, mice exhibit normal retina layers (J:169236)

craniofacial

abnormal cranium morphology ( J:169236 )

• flattened in the anterior posterior axis

small cranium ( J:169236 )

Mouse Models of Human Disease	OMIM ID	Ref(s)
Asphyxiating Thoracic Dystrophy 2; ATD2	611263	J:169236
Short Rib-Polydactyly Syndrome, Type III	263510	J:169236