All Phenotypes Spop<Gt(BGB118)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spop^{Gt(BGB118)Byg}
gene trap BGB118, BayGenomics
MGI:3853475

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spop^{Gt(BGB118)Byg}/Spop^{Gt(BGB118)Byg}	involves: 129P2/OlaHsd * C57BL/6	MGI:4837257
ht2	Spop^{Gt(BGB118)Byg}/Spop⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4837258
cx3	Pdx1^tm1Cvw/Pdx1⁺ Spop^{Gt(BGB118)Byg}/Spop⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837259

Allelic Composition	Spop^{Gt(BGB118)Byg}/Spop^{Gt(BGB118)Byg}
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:165268 )

• although present at E18.5, no mice are present after P1

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:165268 )

• at E18.5, beta cell area is increased 3-fold compared to in wild-type mice

Allelic Composition	Spop^{Gt(BGB118)Byg}/Spop⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N	• beta cell size is normal

abnormal pancreatic islet cell apoptosis ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• beta cell replication is increased compared to in wild-type mice

• however, beta cell replication and apoptosis are balanced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165268 )

N	• mice exhibit normal glucose homeostasis

cellular

abnormal pancreatic islet cell apoptosis ( J:165268 )

Allelic Composition	Pdx1^tm1Cvw/Pdx1⁺ Spop^{Gt(BGB118)Byg}/Spop⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdx1^tm1Cvw mutation (1 available); any Pdx1 mutation (35 available)
Spop^{Gt(BGB118)Byg} mutation (0 available); any Spop mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N	• beta cell mass and the distribution of islet size are normalized unlike in either single heterozygote • mice do not exhibit beta cell apoptosis unlike either single heterozygote

abnormal pancreatic beta cell morphology ( J:165268 )

• beta cell size is decreased compared to in wild-type mice or either single heterozygote

disorganized pancreatic islets ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• beta cell replication is increased compared to in wild-type mice

• endoplasmic reticulum stress is reduced compared to in Pdx1^tm1Cvw heterozygote

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

homeostasis/metabolism

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

increased circulating glucose level ( J:165268 )

improved glucose tolerance ( J:165268 )

• compared with Pdx1^tm1Cvw heterozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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