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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acsbg1tm1Mld
targeted mutation 1, Maria L Dufau
MGI:3851593
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Acsbg1tm1Mld/Acsbg1tm1Mld involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3851594


Genotype
MGI:3851594
hm1
Allelic
Composition
Acsbg1tm1Mld/Acsbg1tm1Mld
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acsbg1tm1Mld mutation (1 available); any Acsbg1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• both males and females are fertile
• at 9 months of age, significant nuclear inclusions are seen in Leydig cells while such inclusions aren't seen in wild-type mice until 15 months of age
• inclusions are surrounded by a single membrane and contain degenerated cytoplasmic components
• enhanced human chorionic gonadotropin induced testosterone production in vivo and impaired gonadotropin induced desensitization in vitro

homeostasis/metabolism
• levels are increased compared to similarly treated controls after a single dose of human chorionic gonadotropin
• however, basal levels are similar to wild-type controls
• decrease in palmitic, oleic and linoleic acid in the adrenal gland
• minor but significant increase in some long chain fatty acids in the testis, ovary and brain
• some very long chain fatty acids are increased in the brain and testis

endocrine/exocrine glands
• at 9 months of age, significant nuclear inclusions are seen in Leydig cells while such inclusions aren't seen in wild-type mice until 15 months of age
• inclusions are surrounded by a single membrane and contain degenerated cytoplasmic components
• enhanced human chorionic gonadotropin induced testosterone production in vivo and impaired gonadotropin induced desensitization in vitro

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Adrenoleukodystrophy; ALD 300100 J:150391





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory