Mouse Genome Informatics
hm1
    Acsbg1tm1Mld/Acsbg1tm1Mld
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
N
• both males and females are fertile (J:150391)
• at 9 months of age, significant nuclear inclusions are seen in Leydig cells while such inclusions aren't seen in wild-type mice until 15 months of age (J:150391)
• inclusions are surrounded by a single membrane and contain degenerated cytoplasmic components (J:150391)
• enhanced human chorionic gonadotropin induced testosterone production in vivo and impaired gonadotropin induced desensitization in vitro (J:150391)

homeostasis/metabolism
• levels are increased compared to similarly treated controls after a single dose of human chorionic gonadotropin
• however, basal levels are similar to wild-type controls
• decrease in palmitic, oleic and linoleic acid in the adrenal gland
• minor but significant increase in some long chain fatty acids in the testis, ovary and brain
• some very long chain fatty acids are increased in the brain and testis

endocrine/exocrine glands
• at 9 months of age, significant nuclear inclusions are seen in Leydig cells while such inclusions aren't seen in wild-type mice until 15 months of age (J:150391)
• inclusions are surrounded by a single membrane and contain degenerated cytoplasmic components (J:150391)
• enhanced human chorionic gonadotropin induced testosterone production in vivo and impaired gonadotropin induced desensitization in vitro (J:150391)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Adrenoleukodystrophy; ALD 300100 J:150391