Phenotypes associated with this allele

• Allele Symbol: Map4k1^tm1Ssaw
• Allele Name: targeted mutation 1, Sansana Sawasdikosol
• Allele ID: MGI:3850713
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map4k1^tm1Ssaw/Map4k1^tm1Ssaw	B6.Cg-Map4k1^tm1Ssaw	MGI:3850717

Genotype
MGI:3850717

hm1

• Allelic Composition: Map4k1^tm1Ssaw/Map4k1^tm1Ssaw
• Genetic Background: B6.Cg-Map4k1^tm1Ssaw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell physiology ( J:150295 )

• dendritic cells have higher levels of activation markers (MHC-II, CD80, CD86) on their surface after LPS stimulation

• less than 30% DCs in culture are pro-apoptotic after 96 hours of LPS stimulation compared to 60% of controls

abnormal dendritic cell antigen presentation ( J:150295 )

• dendritic cells are superior antigen presenters than their wild-type controls

• mice immunized with OVA are able to activate OVA-specific T cells at a higher rate than controls both in vivo and in culture

• these findings are corroborated in mixed lymphocyte cultures where allogenic T cells proliferate more and produce more IL-2 in response to mutant DCs

• tumor-antigen pulsed DCs are more effective in controlling tumors than controls

increased interleukin-1 beta secretion ( J:150295 )

• bone marrow derived dendritic cells secrete more IL-1beta than controls in response to LPS stimulation

increased interleukin-12 secretion ( J:150295 )

• bone marrow derived dendritic cells secrete more IL-12 than controls in response to LPS stimulation

increased interleukin-6 secretion ( J:150295 )

• bone marrow derived dendritic cells secrete more IL-6 than controls in response to LPS stimulation

increased tumor necrosis factor secretion ( J:150295 )