Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation
(6 available);
any
Alpl mutation
(351 available)
Dicer1tm1.1Mnn mutation
(0 available);
any
Dicer1 mutation
(94 available)
Dicer1tm1.2Mnn mutation
(0 available);
any
Dicer1 mutation
(94 available)
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reproductive system
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• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
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• half of the ovulated oocytes exhibit defects in spindles
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cellular
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• half of the ovulated oocytes exhibit defects in spindles and have scattered chromosomes unlike in wild-type oocytes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1.1Mnn mutation
(0 available);
any
Dicer1 mutation
(94 available)
Dicer1tm1.2Mnn mutation
(0 available);
any
Dicer1 mutation
(94 available)
Tg(Zp3-cre)93Knw mutation
(2 available)
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reproductive system
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• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
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• 8 hours post germinal vesicle break-down, oocytes contain abnormal chromosome arrangement and multiple spindles unlike wild-type oocytes
• wild-type germinal vesicles transplanted into oocytes exhibit abnormal meiosis
• however, transplantation of the germinal vesicle into a wild-type oocyte normalizes meiosis
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• 8 hours post germinal vesicle break-down, mutant oocytes contain multiple spindles
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• despite normal numbers of oocytes, female mice are infertile
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cellular
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• nearly all ovulated oocytes exhibit defects in spindle and scattered chromosomes unlike in wild-type oocytes
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Analysis Tools