About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smad9tm3Jfm
targeted mutation 3, James F Martin
MGI:3850120
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smad9tm3Jfm/Smad9tm3Jfm involves: 129S4/SvJaeSor MGI:3850122


Genotype
MGI:3850122
hm1
Allelic
Composition
Smad9tm3Jfm/Smad9tm3Jfm
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad9tm3Jfm mutation (0 available); any Smad9 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions
• perivascular inflammatory infiltrates are seen in the lungs
• seen in 3 of 19 mice

neoplasm
• seen in 3 of 19 mice

embryo
N
• despite expression of the endogenous gene during development no gross developmental abnormalities are seen

cardiovascular system
• beginning at 11.5 months of age vessels in the lung show signs of defective vascular remodeling
• in 6 of 15 mice, distal pulmonary arterioles show hyperplasia with vessel occlusion and plexiform lesions

immune system
• perivascular inflammatory infiltrates are seen in the lungs





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory