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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jag1tm1.1Loo
targeted mutation 1.1, Kathleen M Loomes
MGI:3848155
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Jag1tm1.1Loo/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3848168
cn2
Jag1tm1.1Loo/Jag1+
Notch2tm1Grid/Notch2+
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3848170
cn3
Jag1tm1Grid/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3848171


Genotype
MGI:3848168
cn1
Allelic
Composition
Jag1tm1.1Loo/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1.1Loo mutation (0 available); any Jag1 mutation (35 available)
Tg(Alb1-cre)1Khk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype was observed including in the bile ducts




Genotype
MGI:3848170
cn2
Allelic
Composition
Jag1tm1.1Loo/Jag1+
Notch2tm1Grid/Notch2+
Tg(Alb1-cre)1Khk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1.1Loo mutation (0 available); any Jag1 mutation (35 available)
Notch2tm1Grid mutation (1 available); any Notch2 mutation (39 available)
Tg(Alb1-cre)1Khk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype was observed including in the bile ducts




Genotype
MGI:3848171
cn3
Allelic
Composition
Jag1tm1Grid/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1.1Loo mutation (0 available); any Jag1 mutation (35 available)
Jag1tm1Grid mutation (1 available); any Jag1 mutation (35 available)
Tg(Alb1-cre)1Khk mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age
• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like
• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts
• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts
• bile stasis is identified within the lumina of several proliferating ducts

endocrine/exocrine glands
• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age
• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like
• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts
• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory