Mouse Genome Informatics
cn1
    Jag1tm1.1Loo/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype was observed including in the bile ducts


Mouse Genome Informatics
cn2
    Jag1tm1.1Loo/Jag1+
Notch2tm1Grid/Notch2+
Tg(Alb1-cre)1Khk/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype was observed including in the bile ducts


Mouse Genome Informatics
cn3
    Jag1tm1Grid/Jag1tm1.1Loo
Tg(Alb1-cre)1Khk/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age
• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like
• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts
• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts
• bile stasis is identified within the lumina of several proliferating ducts

endocrine/exocrine glands
• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age
• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like
• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts
• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts