All Phenotypes Jag1<tm1.1Loo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Jag1^tm1.1Loo
targeted mutation 1.1, Kathleen M Loomes
MGI:3848155

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Jag1^tm1Grid/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3848171
cn2	Jag1^tm1.1Loo/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3848168
cn3	Jag1^tm1.1Loo/Jag1⁺ Notch2^tm1Grid/Notch2⁺ Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3848170

Allelic Composition	Jag1^tm1Grid/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1^tm1.1Loo mutation (0 available); any Jag1 mutation (76 available)
Jag1^tm1Grid mutation (1 available); any Jag1 mutation (76 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

bile duct proliferation ( J:149131 )

• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age

• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like

dilated bile duct ( J:149131 )

• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts

• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts

abnormal bile secretion ( J:149131 )

• bile stasis is identified within the lumina of several proliferating ducts

endocrine/exocrine glands

bile duct proliferation ( J:149131 )

• diffuse bile duct proliferation is observed around small and large bile ducts by 4 weeks of age

• by 12 weeks of age, 50% of mice have bile duct proliferation with these ducts appearring small and slit-like

dilated bile duct ( J:149131 )

• at 8 weeks of age, some mice have dilated bile tracts and expanded portal tracts

• cytokeratin staining also shows irregular, dilated ducts surrounding the periphery of many portal tracts

Allelic Composition	Jag1^tm1.1Loo/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1^tm1.1Loo mutation (0 available); any Jag1 mutation (76 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149131 )

• no abnormal phenotype was observed including in the bile ducts

Allelic Composition	Jag1^tm1.1Loo/Jag1⁺ Notch2^tm1Grid/Notch2⁺ Tg(Alb1-cre)1Khk/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1^tm1.1Loo mutation (0 available); any Jag1 mutation (76 available)
Notch2^tm1Grid mutation (1 available); any Notch2 mutation (97 available)
Tg(Alb1-cre)1Khk mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149131 )

• no abnormal phenotype was observed including in the bile ducts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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