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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Cela1-cre/ERT)1Lgdn
transgene insertion 1, Craig Logsdon
MGI:3848026
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0
involves: 129P2/OlaHsd * C57BL/6 MGI:5581459
tg2
Tg(Cela1-cre/ERT)1Lgdn/0 involves: C57BL/6 MGI:3848517


Genotype
MGI:5581459
cn1
Allelic
Composition
Slc39a5tm1Gka/Slc39a5tm1Gka
Tg(Cela1-cre/ERT)1Lgdn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5tm1Gka mutation (1 available); any Slc39a5 mutation (20 available)
Tg(Cela1-cre/ERT)1Lgdn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Slc39a5tm1Gka/Slc39a5tm1Gka Tg(Cela1-cre/ERT)1Lgdn/0 mice exhibit increased sensitivity to zinc-induced acute pancreatitis

homeostasis/metabolism
• in tamoxifen-treated mice
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice
• tamoxifen-treated mice fed excess zinc exhibit reduced pancreatic accumulation due to reduced zinc retention compared with control mice
• however, mice exhibit normal pancreatic zinc uptake

endocrine/exocrine glands
• in tamoxifen-treated mice exposed to zinc
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

liver/biliary system
• in tamoxifen-treated mice

immune system
• tamoxifen-treated mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

digestive/alimentary system
• in tamoxifen-treated mice exposed to zinc




Genotype
MGI:3848517
tg2
Allelic
Composition
Tg(Cela1-cre/ERT)1Lgdn/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cela1-cre/ERT)1Lgdn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile; no further analysis was provided





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory