About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cavin3tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:3847505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg involves: C57BL/6 * C57BL/6NTac MGI:5549945
cx2
Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
involves: C57BL/6 * C57BL/6NTac MGI:5549946


Genotype
MGI:5549945
hm1
Allelic
Composition
Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Cell Lines 11448A-D8
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin3tm1(KOMP)Vlcg mutation (1 available); any Cavin3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• lung vascular endothelial is normal

cellular
N
• endothelial caveolae formation is normal




Genotype
MGI:5549946
cx2
Allelic
Composition
Cavin3tm1(KOMP)Vlcg/Cavin3tm1(KOMP)Vlcg
Cavin2tm1(KOMP)Vlcg/Cavin2tm1(KOMP)Vlcg
Genetic
Background
involves: C57BL/6 * C57BL/6NTac
Cell Lines 11448A-D8, 11065A-H7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin2tm1(KOMP)Vlcg mutation (0 available); any Cavin2 mutation (21 available)
Cavin3tm1(KOMP)Vlcg mutation (1 available); any Cavin3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination
• however, calveolae in the heart is normal
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination

cellular
• lung endothelia contain very few caveolae
• however, calveolae in the heart is normal

respiratory system
• lung endothelia contain very few caveolae with more shallow endothelium membrane invagination





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory