Phenotypes associated with this allele

• Allele Symbol: Stk4^tm1Kina
• Allele Name: targeted mutation 1, Tatsuo Kinashi
• Allele ID: MGI:3847088
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Stk3^tm1.1Jav/Stk3^tm1.1Jav Stk4^tm1Kina/Stk4^tm1Kina Tg(Nkx2-1-cre)2Sand/?	involves: 129 * C57BL/6	MGI:5502638

Genotype
MGI:5502638

cn1

• Allelic Composition: Stk3^tm1.1Jav/Stk3^tm1.1Jav; Stk4^tm1Kina/Stk4^tm1Kina; Tg(Nkx2-1-cre)2Sand/?
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:197340 )

• a markedly sick appearance at birth and almost all mice died within the first 15 d after birt

• born at normal Mendelian ratio

• lung size and dry lung weight were comparable between Mst1/2 dKO mice and control mice at E15.5 and E18.5

respiratory system

increased lung endothelial cell proliferation ( J:197340 )

• at E18.5, lungs showed a markedly increased number of proliferative cells and mildly diminished cell death

• no abnormal proliferation of mesenchymal cells

lung inflammation ( J:197340 )

• displayed spontaneous infiltration of inflammatory cells

• No bacteria and fungi were detected in lung sections or in cytospins of bronchoalveolar lavage fluid, ruling out the possibility of infection

abnormal lung development ( J:197340 )

• Lung Epithelial Cells Causes Abnormal Lung Maturation: Impaired Surfactant Homeostasis and Delayed Differentiation of Type I and II Pneumocytes

• vascularization was normal

abnormal pulmonary alveolus morphology ( J:197340 )

• reduced aerated space compacted with immature-looking cuboidal cells

primary atelectasis ( J:197340 )

• lung showed severe accumulation of inflammatory cells in the alveolar space and bronchiole with multiple atelectasis and emphysematous lesions

emphysema ( J:197340 )

• lung showed severe accumulation of inflammatory cells in the alveolar space and bronchiole with multiple atelectasis and emphysematous lesions

pulmonary hyaline membrane formation ( J:197340 )

• at around post natal day 5

immune system

lung inflammation ( J:197340 )

• displayed spontaneous infiltration of inflammatory cells

• No bacteria and fungi were detected in lung sections or in cytospins of bronchoalveolar lavage fluid, ruling out the possibility of infection

cellular

increased lung endothelial cell proliferation ( J:197340 )

• at E18.5, lungs showed a markedly increased number of proliferative cells and mildly diminished cell death

• no abnormal proliferation of mesenchymal cells