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Allele Symbol Allele Name Allele ID |
Smurf2tm1Wran targeted mutation 1, Jeffrey Wrana MGI:3846786 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die around E10.5 and all mice are dead by E12.5
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• at E8.75, mice exhibit neuroectoderm that is splayed open with ectopic invaginations and an expanded floor plate unlike in wild-type mice
• however, dorso-lateral hinge points form
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• expanded at E8.75
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• 65% of mice display open neural tubes at 6 somite stage unlike wild-type mice
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• 35% of mice display gastrulation defects characterized by abnormal posterior structures
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• the anterior posterior axis is shortened and increased in width compared to in wild-type mice indicative of defective convergent extension movements
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• at E8.75, mice exhibit neuroectoderm that is splayed open with ectopic invaginations and an expanded floor plate unlike in wild-type mice
• however, dorso-lateral hinge points form
|
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• expanded at E8.75
|
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• 65% of mice display open neural tubes at 6 somite stage unlike wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than expected mice are present 24 hours after birth (10% compared to the expected 25%)
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
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• occasionally looped
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• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• fewer than expected mice are present 24 hours after birth (10% compared to the expected 25%)
|
|
• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
|
|
• at 5 and 6 somite stages, mice exhibit delay in bending at the median hinge points compared to in wild-type mice
|
|
• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
|
|
• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
|
|
• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
|
|
• mice exhibit a delay in anterior posterior axis elongation compared with in wild-type mice
|
|
• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
|
|
• at 5 and 6 somite stages, mice exhibit delay in bending at the median hinge points compared to in wild-type mice
|
|
• at E14.5, 25% of mice exhibit neural tube defects including exencephaly and spina bifida unlike wild-type mice
|
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• at 5 and 6 somite stages, the posterior notochord is laterally expanded and reduced length to width ratios compared to in wild-type mice
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• occasionally looped
|
|
• misorientation of cells is most pronounced in the outer hair cell layers with mispositioning of cells also observed
• misoriented outer hair cell are evident in apical and basal surfaces
• outer hair cells display abnormal cell shape and cell-cell contacts resulting in the appearance of pentagonal or heptagonal shaped cells instead of the hexagonal pattern observed in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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