Phenotypes associated with this allele

• Allele Symbol: Ptgs2^tm3Fun
• Allele Name: targeted mutation 3, Colin D Funk
• Allele ID: MGI:3846762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs2^tm3Fun/Ptgs2^tm3Fun	involves: 129S6/SvEvTac * C57BL/6J	MGI:3846763

Genotype
MGI:3846763

hm1

• Allelic Composition: Ptgs2^tm3Fun/Ptgs2^tm3Fun
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:148699 )

N • unlike mice homozygous for Ptgs2^tm1.1Fun, no signs of perivascular to interstitial inflammation are seen

abnormal urine homeostasis ( J:148699 )

• decrease in the urine level of 2,3-dinor-6-keto-PGF1alpha, the major urinary metabolite of prostacyclin metabolism

abnormal renal glomerulus morphology ( J:148699 )

• moderate multifocal hypoplasia of glomerular tufts within the superficial renal cortex

• mild, multifocal glomerular hyperplasia within the deeper cortex

abnormal renal tubule morphology ( J:148699 )

• mild to moderate, multifocal tubular degeneration and regeneration particularly within the superficial cortex

homeostasis/metabolism

increased platelet aggregation ( J:148699 )

• following vessel injury with FeCl3 the overall formation of platelet aggregates is increased compared to wild-type controls

increased blood urea nitrogen level ( J:148699 )

• mild increase

increased susceptibility to induced thrombosis ( J:148699 )

• increase in the propensity for thrombogenesis in response to FeCl3 induced injury

abnormal urine homeostasis ( J:148699 )

• decrease in the urine level of 2,3-dinor-6-keto-PGF1alpha, the major urinary metabolite of prostacyclin metabolism

cardiovascular system

cardiovascular system phenotype ( J:148699 )

N • despite association of PTGS2 inhibition with moderate risk of hypertension, blood pressure is not significantly different from wild-type controls

hematopoietic system

increased platelet aggregation ( J:148699 )

• following vessel injury with FeCl3 the overall formation of platelet aggregates is increased compared to wild-type controls