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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hprttm1(CAG-Tgfbr1*)Lba
targeted mutation 1, Laurent Bartholin
MGI:3846738
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Hprttm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3846745
cn2
Hprttm1(CAG-Tgfbr1*)Lba/Hprttm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3846748
cn3
Hprttm1(CAG-Tgfbr1*)Lba/Hprttm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 MGI:3846742
cn4
Hprttm1(CAG-Tgfbr1*)Lba/Y
Tg(Cd4-cre)1Cwi/0
involves: 129 * C57BL/6 * DBA/2 MGI:3846744


Genotype
MGI:3846745
cn1
Allelic
Composition
Hprttm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (8 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• these mice do not have the wasting autoimmune disease normally observed in mice with conditional deletion of Tgfbr2 in CD4+ T cells




Genotype
MGI:3846748
cn2
Allelic
Composition
Hprttm1(CAG-Tgfbr1*)Lba/Hprttm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (8 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• these mice do not have the wasting autoimmune disease normally observed in mice with conditional deletion of Tgfbr2 in CD4+ T cells




Genotype
MGI:3846742
cn3
Allelic
Composition
Hprttm1(CAG-Tgfbr1*)Lba/Hprttm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

immune system
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal




Genotype
MGI:3846744
cn4
Allelic
Composition
Hprttm1(CAG-Tgfbr1*)Lba/Y
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprttm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

hematopoietic system
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory