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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CAG-Tgfbr1*)Lba
targeted mutation 1, Laurent Bartholin
MGI:3846738
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0 		involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3846745
cn2
 		Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0 		involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3846748
cn3
 		Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 MGI:3846742
cn4
 		Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tg(Cd4-cre)1Cwi/0 		involves: 129 * C57BL/6 * DBA/2 MGI:3846744


Genotype
MGI:3846745
cn1
Allelic
Composition		 Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:148747 )
N
• these mice do not have the wasting autoimmune disease normally observed in mice with conditional deletion of Tgfbr2 in CD4+ T cells




Genotype
MGI:3846748
cn2
Allelic
Composition		 Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:148747 )
N
• these mice do not have the wasting autoimmune disease normally observed in mice with conditional deletion of Tgfbr2 in CD4+ T cells




Genotype
MGI:3846742
cn3
Allelic
Composition		 Hprt1tm1(CAG-Tgfbr1*)Lba/Hprt1tm1(CAG-Tgfbr1*)Lba
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

immune system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal




Genotype
MGI:3846744
cn4
Allelic
Composition		 Hprt1tm1(CAG-Tgfbr1*)Lba/Y
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-Tgfbr1*)Lba mutation (0 available); any Hprt1 mutation (1274 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal

hematopoietic system
abnormal T cell activation ( J:148747 )
• T cell receptor activation is highly repressed
• steady-state activation of T cells is normal




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory