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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmox1tm1.2Gkl
targeted mutation 1.2, George Kollias
MGI:3846093
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmox1tm1.2Gkl/Hmox1tm1.2Gkl involves: 129 * BALB/cJ * C57BL/6 MGI:3846106


Genotype
MGI:3846106
hm1
Allelic
Composition		 Hmox1tm1.2Gkl/Hmox1tm1.2Gkl
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmox1tm1.2Gkl mutation (1 available); any Hmox1 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Chronic inflammatory disease in Hmox1tm1.2Gkl/Hmox1tm1.2Gkl mice

mortality/aging
premature death ( J:148498 )
• mice die within 6 months because of multiorgan failure
postnatal lethality, incomplete penetrance ( J:148498 )
• mice exhibit partial lethality similar to that observed in Hmox1tm1Poss homozygotes

immune system
increased inflammatory response ( J:148498 )
• mice develop progressive chronic and inflammatory disease unlike wild-type mice
liver inflammation ( J:148498 )
• mice exhibit hepatic inflammatory lesions unlike wild-type mice

liver/biliary system
liver inflammation ( J:148498 )
• mice exhibit hepatic inflammatory lesions unlike wild-type mice

hematopoietic system

growth/size/body
enlarged spleen ( J:148498 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory