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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rsad2tm1Kchc
targeted mutation 1, Keh-Chuang Chin
MGI:3844545
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rsad2tm1Kchc/Rsad2tm1Kchc B6.129-Rsad2tm1Kchc MGI:3844555


Genotype
MGI:3844555
hm1
Allelic
Composition
Rsad2tm1Kchc/Rsad2tm1Kchc
Genetic
Background
B6.129-Rsad2tm1Kchc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rsad2tm1Kchc mutation (0 available); any Rsad2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T-helper 2 cell differentiation and cytokine production is impaired following stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies, phorbol-12- myristate-13-acetate with ionomycin, or strong TCR-mediated suboptimal Th2 polarization regardless of the presence of absence of exogenous IL4
• 2 weeks following the second immunization with ovalbumin, mice produce 2-fold less ovalbumin-specific IgG1 compared to similarly treated wild-type mice
• 24 hours after stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies, IFN-gamma production is moderately increased compared to similarly treated wild-type cells
• when stimulated with strong TCR-mediated suboptimal Th2 polarization regardless of the presence of absence of exogenous IL4, IFN-gamma production is moderately increased compared to similarly treated wild-type cells
• however, IFN-gamma production after 72 hours of stimulation with anti-CD3 and anti-CD28 antibodies or optimal TCR signaling is normal
• 24 hours after stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies or phorbol-12- myristate-13-acetate with ionomycin, CD4+ T cells exhibit decreased IL13 production compared to similarly treated wild-type cells
• after stimulation with strong TCR-mediated suboptimal Th2 polarization with exogenous IL4 expression, IL13 production is less than in similarly treated wild-type cells
• however, IL13 production after 72 hours of stimulation with anti-CD3 and anti-CD28 antibodies or optimal Th2 conditions is normal
• 24 hours after stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies or phorbol-12- myristate-13-acetate with ionomycin, CD4+ T cells exhibit decreased IL4 production compared to similarly treated wild-type cells
• after stimulation with strong TCR-mediated suboptimal Th2 polarization with exogenous IL4 expression, IL4 production is less than in similarly treated wild-type cells
• however, IL4 production after 72 hours of stimulation with anti-CD3 and anti-CD28 antibodies or optimal Th2 conditions is normal
• 24 hours after stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies or phorbol-12- myristate-13-acetate with ionomycin, CD4+ T cells exhibit decreased IL5 production compared to similarly treated wild-type cells
• after stimulation with strong TCR-mediated suboptimal Th2 polarization with exogenous IL4 expression, IL5 production is less than in similarly treated wild-type cells
• however, IL5 production after 72 hours of stimulation with anti-CD3 and anti-CD28 antibodies or optimal Th2 conditions is normal

hematopoietic system
• T-helper 2 cell differentiation and cytokine production is impaired following stimulation with anti-CD3 antibodies with or without anti-CD28 antibodies, phorbol-12- myristate-13-acetate with ionomycin, or strong TCR-mediated suboptimal Th2 polarization regardless of the presence of absence of exogenous IL4
• 2 weeks following the second immunization with ovalbumin, mice produce 2-fold less ovalbumin-specific IgG1 compared to similarly treated wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory