Phenotypes associated with this allele

• Allele Symbol: Sirt7^tm1Evbo
• Allele Name: targeted mutation 1, Eva Bober
• Allele ID: MGI:3842304
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sirt7^tm1Evbo/Sirt7^tm1Evbo	involves: 129/Sv * C57BL/6	MGI:3842339

Genotype
MGI:3842339

hm1

• Allelic Composition: Sirt7^tm1Evbo/Sirt7^tm1Evbo
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147652 )

• mean and maximum life span is reduced by 59% and 55%, respectively, compared to in wild-type mice

premature aging ( J:147652 )

• mice develop kyphosis and loss of subcutaneous fat earlier in life than wild-type mice

cardiovascular system

increased myocardial fiber size ( J:147652 )

• mice exhibit an increase in cardiac myocyte cross-sectional area and increased variability in cross-sectional areas compared to in wild-type mice

increased heart weight ( J:147652 )

• at 7 to 11 months, mice exhibit increased heart weight to body weight compared to wild-type mice that becomes more pronounced with age

cardiac hypertrophy ( J:147652 )

• at 7 to 11 months, mice exhibit degenerative cardiac hypertrophy that becomes more pronounced with age

cardiac fibrosis ( J:147652 )

• at 9 months of age

increased cardiomyocyte apoptosis ( J:147652 )

• at 5 months, cardiomyocyte apoptosis is increased 200% compared to in wild-type mice

• in culture, cardiomyocytes exhibit a 2-fold increase in the number of cells undergoing apoptosis compared to wild-type cells

cardiomyopathy ( J:147652 )

immune system

increased granulocyte number ( J:147652 )

• 3-fold at 5 months of age

abnormal cytokine level ( J:147652 )

• at 2 months of age, IGFBP-3 expression in the myocardium is increased compared to in wild-type mice

increased interleukin-12 secretion ( J:147652 )

• 200% in the myocardium at 2 months of age

increased interleukin-13 secretion ( J:147652 )

• 300% in the myocardium at 2 months of age

increased interleukin-4 secretion ( J:147652 )

• in the myocardium at 2 months of age

cellular

increased cardiomyocyte apoptosis ( J:147652 )

• at 5 months, cardiomyocyte apoptosis is increased 200% compared to in wild-type mice

• in culture, cardiomyocytes exhibit a 2-fold increase in the number of cells undergoing apoptosis compared to wild-type cells

increased sensitivity to induced cell death ( J:147652 )

• primary cardiomyocytes exhibit increased cellular sensitivity to hydrogen peroxide compared to wild-type cells

increased cellular sensitivity to hydrogen peroxide ( J:147652 )

• primary cardiomyocytes exhibit increased cellular sensitivity to hydrogen peroxide compared to wild-type cells

adipose tissue

decreased subcutaneous adipose tissue amount ( J:147652 )

• earlier in life than wild-type mice

homeostasis/metabolism

abnormal cytokine level ( J:147652 )

• at 2 months of age, IGFBP-3 expression in the myocardium is increased compared to in wild-type mice

abnormal response to injury ( J:147652 )

• mice exhibit a general decrease in stress-resistance mechanism compared to wild-type mice

pigmentation

lipofuscinosis ( J:147652 )

• at 5 months, lipofuscin accumulates in the myocardium unlike in wild-type mice

skeleton

kyphosis ( J:147652 )

• earlier in life than wild-type mice

hematopoietic system

increased granulocyte number ( J:147652 )

• 3-fold at 5 months of age

muscle

increased myocardial fiber size ( J:147652 )

• mice exhibit an increase in cardiac myocyte cross-sectional area and increased variability in cross-sectional areas compared to in wild-type mice

increased cardiomyocyte apoptosis ( J:147652 )

• at 5 months, cardiomyocyte apoptosis is increased 200% compared to in wild-type mice

• in culture, cardiomyocytes exhibit a 2-fold increase in the number of cells undergoing apoptosis compared to wild-type cells

cardiomyopathy ( J:147652 )

integument

decreased subcutaneous adipose tissue amount ( J:147652 )

• earlier in life than wild-type mice

growth/size/body

increased heart weight ( J:147652 )

• at 7 to 11 months, mice exhibit increased heart weight to body weight compared to wild-type mice that becomes more pronounced with age

cardiac hypertrophy ( J:147652 )

• at 7 to 11 months, mice exhibit degenerative cardiac hypertrophy that becomes more pronounced with age