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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53bp2tm1Cdlo
targeted mutation 1, Charles D Lopez
MGI:3839864
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp53bp2tm1Cdlo/Trp53bp2tm1Cdlo involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3839865
ht2
 		Trp53bp2tm1Cdlo/Trp53bp2+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3839866
cx3
 		Trp53tm1Brd/Trp53+
Trp53bp2tm1Cdlo/Trp53bp2+ 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3839867
cx4
 		Trp53bp2tm1Cdlo/Trp53bp2+
Tg(EmuSR-tTa)83Bop/0
Tg(tetO-MYC)36aBop/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3839868


Genotype
MGI:3839865
hm1
Allelic
Composition		 Trp53bp2tm1Cdlo/Trp53bp2tm1Cdlo
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:146764 )
• unable to characterize homozygous embryos at E6.5




Genotype
MGI:3839866
ht2
Allelic
Composition		 Trp53bp2tm1Cdlo/Trp53bp2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:146764 )
• increased tumor incidence but the spectrum of tumor types is similar to controls
increased incidence of tumors by ionizing radiation induction ( J:146764 )
• unlike wild-type controls, mice develop tumors following exposure to 6.0 Gy or 10.5 Gy of gamma-radiation
• induced tumors are high grade lymphomas

immune system
abnormal T cell physiology ( J:146764 )
• attenuated T cell apoptotic response following gamma-irradiation

cellular
abnormal cell cycle checkpoint function ( J:146764 )
• attenuated G0/G1 checkpoint function following gamma-irradiation

hematopoietic system
abnormal T cell physiology ( J:146764 )
• attenuated T cell apoptotic response following gamma-irradiation




Genotype
MGI:3839867
cx3
Allelic
Composition		 Trp53tm1Brd/Trp53+
Trp53bp2tm1Cdlo/Trp53bp2+
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53bp2tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:146764 )
• increased tumor incidence compared to wild-type controls but not compared to mice heterozygous for the Trp53 allele alone




Genotype
MGI:3839868
cx4
Allelic
Composition		 Trp53bp2tm1Cdlo/Trp53bp2+
Tg(EmuSR-tTa)83Bop/0
Tg(tetO-MYC)36aBop/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-MYC)36aBop mutation (1 available)
Trp53bp2tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:146764 )
• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:146764 )
• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory