Mouse Genome Informatics
cx1
    Per2tm1Drw/Per2tm1Drw
Tg(PER2*S662G)867Ljp/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• circadian period is shortened 3.3 hours compared to in wild-type mice
• however, mice under LD10.5:10.5 conditions exhibit normal on-off activity patterns


Mouse Genome Informatics
cx2
    Csnk1dGt(TEA020)Byg/Csnk1d+
Tg(PER2*S662G)867Ljp/0

involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• circadian period is shortened 1.5 hours compared to in wild-type mice


Mouse Genome Informatics
cx3
    Tg(CSNK1D,-EGFP)#Yfu/0
Tg(PER2*S662G)867Ljp/0

involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• circadian period is shortened 3.2 hours compared to in wild-type mice


Mouse Genome Informatics
tg4
    Tg(PER2*S662G)867Ljp/0
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• circadian period is 0.7 hours longer than in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Advanced Sleep Phase Syndrome, Familial, 1; FASPS1 604348 J:126404