Analysis Tools
mortality/aging
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• most mutant embryos look grossly abnormal and some of them start to die at E14.5
• mutant embryos appear to be phenotypically normal at E12.5
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cardiovascular system
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• delayed development of myofibrils resulting in scarce, disorganized myofibrils
• the myofibril structure and connections between the myocytes were disrupted
• sarcomere were collapsed at E14.5
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• the filaments within a myofibril approaching the intercalated disk at different angles resulting in tapered, frayed and/or disorganized or disconnected morphology
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• thin walls owing to the reduced size of the compact zone of the myocardium
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hemorrhage
(
J:144625
)
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• in E14.5 embryos
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• of myocytes isolated from mutant embryo show reduced and abnormal contractility in culture
|
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• the abolishment of actin arginylation was observed in alpha cardiac actin from E12.5 hearts
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muscle
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• delayed development of myofibrils resulting in scarce, disorganized myofibrils
• the myofibril structure and connections between the myocytes were disrupted
• sarcomere were collapsed at E14.5
|
|
• the filaments within a myofibril approaching the intercalated disk at different angles resulting in tapered, frayed and/or disorganized or disconnected morphology
|
|
• thin walls owing to the reduced size of the compact zone of the myocardium
|
|
• of myocytes isolated from mutant embryo show reduced and abnormal contractility in culture
|
embryo
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• in E14.5 embryos
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integument
