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Allele Symbol Allele Name Allele ID |
Tg(TcraTcrbAD10)1Hed transgene insertion 1, Stephen M Hedrick MGI:3835444 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD4 single-positive thymocytes make up 37% of the total thymocyte population, which is 3-4 fold greater than controls
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• CD4 single-positive thymocytes make up 37% of the total thymocyte population, which is 3-4 fold greater than controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the number of CD4 single-positive thymocytes are severely reduced in these mice
• peripheral CD4+ T cells are reduced from 41% of lymph node cells to 14%
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• negative selection of transgenic T cells leads to diminished CD4 T cells in the periphery
• apoptotic cells resulting from negative selection are found at the cortico-medullary and medullary portions of the thymus
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• T cells that escape central tolerance are able to respond to pigeon cytochrome-c but 10 times as much protein is needed to get a comparable response to Tg(TcrAND)53Hed transgenic
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• the number of CD4 single-positive thymocytes are severely reduced in these mice
• peripheral CD4+ T cells are reduced from 41% of lymph node cells to 14%
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• the number of CD4 single-positive thymocytes are severely reduced in these mice
• peripheral CD4+ T cells are reduced from 41% of lymph node cells to 14%
|
|
• negative selection of transgenic T cells leads to diminished CD4 T cells in the periphery
• apoptotic cells resulting from negative selection are found at the cortico-medullary and medullary portions of the thymus
|
|
• T cells that escape central tolerance are able to respond to pigeon cytochrome-c but 10 times as much protein is needed to get a comparable response to Tg(TcrAND)53Hed transgenic
|
|
• the number of CD4 single-positive thymocytes are severely reduced in these mice
• peripheral CD4+ T cells are reduced from 41% of lymph node cells to 14%
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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