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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mbl1tm1Rala
targeted mutation 1, Rachel A Lawrence
MGI:3834180
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mbl1tm1Rala/Mbl1tm1Rala involves: 129X1/SvJ * C57BL/6J MGI:3834184


Genotype
MGI:3834184
hm1
Allelic
Composition
Mbl1tm1Rala/Mbl1tm1Rala
Genetic
Background
involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mbl1tm1Rala mutation (0 available); any Mbl1 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi
• significantly elevated levels of specific antibody relative to controls at days 15 and 22 after infection with Brugia malayi
• significantly reduced response to immunization with OVA
• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi
• levels of specific antibody relative to controls at day 15 after infection with Brugia malayi are very low
• response to challenge with OVA is also very low
• Brugia malayi infections reach significantly higher levels by 7 days after infection than controls
• significant parasite load at 28 days after infection whereas control mice have completely cleared their infections

hematopoietic system
• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi
• significantly elevated levels of specific antibody relative to controls at days 15 and 22 after infection with Brugia malayi
• significantly reduced response to immunization with OVA
• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi
• levels of specific antibody relative to controls at day 15 after infection with Brugia malayi are very low
• response to challenge with OVA is also very low





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory