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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2rx4tm1Dgen
targeted mutation 1, Deltagen
MGI:3834163
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		P2rx4tm1Dgen/P2rx4tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3834170


Genotype
MGI:3834170
hm1
Allelic
Composition		 P2rx4tm1Dgen/P2rx4tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx4tm1Dgen mutation (0 available); any P2rx4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:145232 )
• at intermediate concentration of ATP, no P2X4-like current is observed unlike in wild-type macrophages
• at high concentrations of ATP, 100% of macrophages exhibit a P2X7-like current compared to 85% of wild-type macrophages

hematopoietic system
abnormal macrophage physiology ( J:145232 )
• at intermediate concentration of ATP, no P2X4-like current is observed unlike in wild-type macrophages
• at high concentrations of ATP, 100% of macrophages exhibit a P2X7-like current compared to 85% of wild-type macrophages




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory