Phenotypes associated with this allele

• Allele Symbol: Trafd1^tm1Ayos
• Allele Name: targeted mutation 1, Akihiko Yoshimura
• Allele ID: MGI:3831676
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trafd1^tm1Ayos/Trafd1^tm1Ayos	involves: 129 * C57BL/6J	MGI:3831685

Genotype
MGI:3831685

hm1

• Allelic Composition: Trafd1^tm1Ayos/Trafd1^tm1Ayos
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:144594 )

• following treatment with LPS or poly(I:C), mice exhibit increased mortality compared to wild-type mice

immune system

increased circulating interleukin-6 level ( J:144594 )

• following treatment with poly(I:C)

increased interleukin-12 secretion ( J:144594 )

• following treatment with LPS, bone marrow-derived dendritic cells produce more IL12p70 compared to similarly treated wild-type cells

increased interleukin-6 secretion ( J:144594 )

• following treatment with LPS, bone marrow-derived dendritic cells produce more IL6 compared to similarly treated wild-type cells

increased tumor necrosis factor secretion ( J:144594 )

• following treatment with LPS, bone marrow-derived dendritic cells produce more TNF-alpha compared to similarly treated wild-type cells

increased susceptibility to endotoxin shock ( J:144594 )

• following treatment with LPS or poly(I:C), mice exhibit increased mortality and cytokine production compared to wild-type mice

decreased susceptibility to Riboviria infection ( J:144594 )

• mouse embryonic fibroblasts are more resistant to the cytopathic effects of viral infection with VSV (vesicular stomatitis virus) compared to wild-type cells

• however, the efficiency of primary infection is normal

homeostasis/metabolism

increased circulating interleukin-6 level ( J:144594 )

• following treatment with poly(I:C)

increased circulating alanine transaminase level ( J:144594 )

• following treatment with poly(I:C)